Repurposed drug thalidomide shows promise for hard-to-treat brain and spinal cord arteriovenous malformations
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Oct-2026 06:16 ET (30-Oct-2026 10:16 GMT/UTC)
Researchers developed a KRAS-driven mouse model of sporadic brain arteriovenous malformation and identified thalidomide as a candidate therapy. In mice, thalidomide improved survival, reduced lesion growth, and stabilized abnormal vessels. In a proof-of-concept clinical study, most evaluable patients showed stable or regressed lesions.
Efficient electrochemical nitrate reduction to ammonia requires not only active catalysts, but also precise control over active hydrogen utilization under industrial operating conditions. By introducing cerium into Cu2O, we constructed Cu0-Cu+ and Cu-O-Ce dual active sites, enabling the regulation of hydrogen transfer pathways and suppressing the competing hydrogen evolution reaction to promote the selective nitrate-to-ammonia conversion.
Researchers have released the conceptual design of the Huizhou Hadron Spectrometer (HHaS), a next-generation experiment to be built at the High-Intensity Heavy-Ion Accelerator Facility (HIAF) in Huizhou, Guangdong Province, China. HHaS aims for an unprecedented event rate of 1–100 MHz, with ~1% momentum resolution, ~3% electromagnetic energy resolution, and mm-level track pointing precision. With one month of running, HHaS can record an η meson sample three orders of magnitude larger than the world’s total existing data—enabling sensitivity for new physics searches two orders of magnitude beyond current limits.
A tough and notch-insensitive conductive hydrogel is developed by introducing L-arginine-regulated polyoxometalatenano-crosslinking domains. The hydrogel exhibits high stretchability, robust ionic conductivity, and sensitive strain sens-ing, enabling stable electrocardiogram (ECG) and electromyography (EMG) signal monitoring for wearable bioelectronics.
A research paper by scientists from Beijing Institute of Technology proposed a maxillofacial tumor treatment system termed RAMRS, comprising 2 modules: robot-assisted osteotomy and augmented reality-guided reconstruction (ARR).
The new research paper, published on May. 22 in the journal Cyborg and Bionic Systems, developed RAMRS – a robot‑assisted and augmented reality‑guided maxillofacial reconstruction system.