A rapid, precise, on-site, portable, and naked-eye visualization method for genotyping the FecBB mutation in sheep has been established. A genotyping strategy for important SNP site in livestock breeding programmes is provided, theoretically applicable to any SNP site.

Researchers demonstrated a superconducting qubit sensor that combines quantum criticality and non-equilibrium dynamics to estimate gradient fields with precision approaching the fundamental precision limits using simple measurements.

The study investigated the influence of volcanic activity on centennial-scale variability of Northern Hemisphere land monsoon rainfall during the Holocene. Using a transient Holocene climate simulation (iTraCE) that incorporates volcanic forcing, greenhouse gas concentrations, orbital parameters, freshwater forcing, and ice-sheet changes, the team explored the long-term role of volcanic activity in shaping monsoon evolution.

Dynamic treatment represents the cornerstone of precision medicine. However, the development of closed-loop systems that respond to endogenous biomarkers remains challenging. Here, we report a dual-channel flexible electrocatalytic system (Pd-Ni₅P₄/DCEFS) integrated into a microneedle array that enables ultrasensitive real-time monitoring of nitric oxide (NO)—a key biomarker of wound inflammation—with a detection limit of 9.6 nM, while simultaneously driving the hydrogen evolution reaction with a low overpotential of − 91.0 mV at − 10 mA cm⁻². This integrated platform establishes a closed-loop sensing-feedback-intervention mechanism, enabling NO-guided on-demand hydrogen generation for precision anti-inflammatory treatment. In diabetic mouse skin wound models, this adaptive hydrogen production strategy markedly suppresses inflammation, promotes tissue regeneration, achieves substantial wound closure within 5 days, and reduces the overall healing time to 11 days. This study establishes a new paradigm for closed-loop dynamic treatment of inflammatory diseases and provides a critical foundation for next-generation self-adaptive therapeutic platforms in regenerative medicine.

Scientists from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences have explained themicrostructure formation mechanism of nonsolvent-induced phase separation (NIPS) by separating the formation processesof different pore structure. Based on the findings, the team developed a free-standing ultrathin porous polymeric membrane with a thickness of only 2.7 μm that simultaneously offers high selectivity and high conductivity. When applied in a vanadium flow battery, the membrane demonstrated outstanding electrochemical performance.

Machine learning (ML) is reshaping pipeline integrity management (PIM) from physics-based to data-driven paradigms. This systematic review comprehensively surveys ML applications across pipeline reliability design, integrity assessment, inspection, and maintenance; identifies key bottlenecks including data scarcity, poor interpretability, and limited field validation; and proposes a research roadmap toward tractable, trustworthy ML for full-lifecycle pipeline safety.

Researchers have developed a new polymer electrolyte that enables lithium metal batteries to operate safely at high voltages and across an extreme temperature range, from -40°C to 55°C. The material directly addresses two long-standing barriers to next-generation energy storage: poor oxidation stability and insufficient ionic conductivity. By tuning the molecular structure of the electrolyte and creating a cross-linked network, the team achieved exceptional electrochemical stability and rapid ion transport. This advance brings high-energy-density lithium metal batteries—promising longer-range electric vehicles and more reliable portable electronics—significantly closer to practical, real-world application.

As heat waves become more frequent, leafy vegetables face rising risks of yield loss, quality decline, and shortened production windows.

A research team has developed an enzyme-aware digital model that explains why hydrogen-producing microbes often struggle to grow fast and generate hydrogen efficiently at the same time. 

Study reveals north–south differences in water isotopes across North America during the last deglaciation