Dynamic treatment represents the cornerstone of precision medicine. However, the development of closed-loop systems that respond to endogenous biomarkers remains challenging. Here, we report a dual-channel flexible electrocatalytic system (Pd-Ni₅P₄/DCEFS) integrated into a microneedle array that enables ultrasensitive real-time monitoring of nitric oxide (NO)—a key biomarker of wound inflammation—with a detection limit of 9.6 nM, while simultaneously driving the hydrogen evolution reaction with a low overpotential of − 91.0 mV at − 10 mA cm⁻². This integrated platform establishes a closed-loop sensing-feedback-intervention mechanism, enabling NO-guided on-demand hydrogen generation for precision anti-inflammatory treatment. In diabetic mouse skin wound models, this adaptive hydrogen production strategy markedly suppresses inflammation, promotes tissue regeneration, achieves substantial wound closure within 5 days, and reduces the overall healing time to 11 days. This study establishes a new paradigm for closed-loop dynamic treatment of inflammatory diseases and provides a critical foundation for next-generation self-adaptive therapeutic platforms in regenerative medicine.

Scientists from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences have explained themicrostructure formation mechanism of nonsolvent-induced phase separation (NIPS) by separating the formation processesof different pore structure. Based on the findings, the team developed a free-standing ultrathin porous polymeric membrane with a thickness of only 2.7 μm that simultaneously offers high selectivity and high conductivity. When applied in a vanadium flow battery, the membrane demonstrated outstanding electrochemical performance.

Machine learning (ML) is reshaping pipeline integrity management (PIM) from physics-based to data-driven paradigms. This systematic review comprehensively surveys ML applications across pipeline reliability design, integrity assessment, inspection, and maintenance; identifies key bottlenecks including data scarcity, poor interpretability, and limited field validation; and proposes a research roadmap toward tractable, trustworthy ML for full-lifecycle pipeline safety.

Researchers have developed a new polymer electrolyte that enables lithium metal batteries to operate safely at high voltages and across an extreme temperature range, from -40°C to 55°C. The material directly addresses two long-standing barriers to next-generation energy storage: poor oxidation stability and insufficient ionic conductivity. By tuning the molecular structure of the electrolyte and creating a cross-linked network, the team achieved exceptional electrochemical stability and rapid ion transport. This advance brings high-energy-density lithium metal batteries—promising longer-range electric vehicles and more reliable portable electronics—significantly closer to practical, real-world application.

As heat waves become more frequent, leafy vegetables face rising risks of yield loss, quality decline, and shortened production windows.

A research team has developed an enzyme-aware digital model that explains why hydrogen-producing microbes often struggle to grow fast and generate hydrogen efficiently at the same time. 

Study reveals north–south differences in water isotopes across North America during the last deglaciation

Pancreatic cancer has a 5-year survival rate below 15%, with surgical resection as the only curative option. A new review highlights photon-counting CT (PCCT)’s advantages over conventional CT, including ultra-high spatial resolution and spectral imaging. It enhances tumor delineation, vascular/lymphatic assessment, and surgical planning, though challenges remain for wider adoption.

Achieving high safety in energy storage systems is paramount but hindered by the catastrophic risks of thermal runaway propagation (TRP). This study develops a gradient-laminated ceramifiable silicone foam composite to resolve the inherent trade-off between thermal insulation and dynamic impact toughness. By integrating a polydimethylsiloxane foam matrix with a load-bearing glass fiber fabric skeleton, the material utilizes silane coupling agents for robust interfacial adhesion, while multiscale fillers promote synergistic ceramicization. Characterization reveals robust mechanical durability, maintaining stable elasticity across a wide temperature range (− 40 to 300 °C) and retaining 93% residual stress after 1,000 compression cycles. Under extreme thermal exposure, the foam transforms into a dense ceramic barrier, reducing total heat release by 54.4% and sustaining thermal protection for over 30 min. Crucially, during battery module testing, this architecture efficiently intercepts high-velocity gas jets and confines thermal runaway to a single cell. Fabricated via a scalable process, this composite paves a viable way for constructing intrinsically safe energy storage systems.

Scientists reveal how exercise eases osteoarthritis: mechanical joint loading helps red blood cell‑derived EVs carry oxygen into cartilage and meniscus. These EVs enter avascular tissues via HRG (histidine rich glycoprotein)‑HSPG (heparin sulfate proteoglycan) affinity mechanism, directed by hypoxia‑induced CXCL12/CXCR4 signaling. The study establishes a “circulation‑joint transport axis” that alleviates intra‑articular hypoxia, offering a non‑drug strategy for joint health.