A new mechanism based on the natural compound chipericumin D from Hypericum monogynum to inhibit osteogenic differentiation in calcific aortic valve disease (CAVD) by directly targeting EGFR and suppressing the EGFR/PI3K/AKT signaling pathway is provided, and a new strategy for CAVD drug therapy is opened.

Substrate inhibition is a longstanding bottleneck in microbial fermentation, particularly in lactic acid bacteria, where excessive substrate concentrations can paradoxically suppress growth and product formation. Conventional models, such as Haldane type formulations, are widely used but remain largely phenomenological, limiting their interpretability and predictive power for process optimization. Bridging this gap requires models that not only fit experimental data but also capture the underlying biological mechanisms.

Researchers at Nanjing University developed platinum(IV)-antibody conjugates that enhance tumor immunogenicity without relying on strong cancer cell killing. The targeted system delivers low-dose platinum selectively to tumors, increasing MHC-I expression and improving immune recognition while reducing systemic toxicity. In mouse models, the strategy significantly enhanced the efficacy of anti-PD-1 immunotherapy.

Wearable smart sensors for monitoring human motion have emerged as an active area of research due to their potential applications in healthcare, sports performance, and human–machine interaction. These devices must not only provide accurate sensing capabilities but also be flexible, portable, and comfortable to integrate seamlessly into daily life. Conventional textiles, while widely used, are no longer sufficient to meet the functional demands of contemporary users. As a result, the textile industry is evolving toward functionalization and intelligence, with smart fabrics gaining increasing attention.

Layered double hydroxides (LDHs) exhibit excellent catalytic performance due to their unique two-dimensional (2D) layered structure, adjustable chemical composition, and tunable interlayer ion types and contents. However, when employed as a catalyst, LDH materials still suffer from several drawbacks, such as poor electrical conductivity and a tendency to agglomerate. To further improve their catalytic performance, a variety of effective modification strategies have been adopted, including electronic structure modulation, morphological control, and interface engineering.

A research team has mapped how artificial intelligence is beginning to reshape cardiac arrest care, from early warning and emergency response to cardiopulmonary resuscitation and recovery after survival. By reviewing 114 studies involving more than 9.57 million patients, the study shows that artificial intelligence is most often used to predict cardiac arrest, guide resuscitation decisions, and estimate post-arrest outcomes. The findings suggest that artificial intelligence could become a practical tool for identifying high-risk patients earlier, supporting time-critical decisions during resuscitation, and improving post-arrest care, while also highlighting the need for stronger real-world validation before these tools can be widely adopted in emergency medicine.

Researchers at the University of New South Wales and Monash University in Australia have developed a new method for covert communications. By taking advantage of the phenomena of “negative luminescence”, the opposite of the electroluminescence of conventional visible light emitting diodes (LEDs), they demonstrate that a data signal can be perfectly hidden in the thermal background, with only an outside observer with the same technology able to observe that a message was sent at all.

Achieving Zn anode stability is critical for advancing commercialization of aqueous zinc-ion batteries. However, the instability of zinc metal anodes driven by dendritic growth, hydrogen evolution, and interfacial passivation remains a critical obstacle for advancing aqueous zinc-ion batteries. In this paper, we report a synergistic interfacial engineering strategy that integrates in situ-grown zincophilic copper nanorod arrays with a self-assembled layer of 1-dodecanethiol to regulate ion flux and suppress side reactions simultaneously. The water-poor electric double-layer microenvironment derived from this dual-function “zincophilic–hydrophobic” architecture (denoted as HS-Cu@Zn) promotes uniform Zn deposition along the (100) plane, enhances desolvation kinetics (Zn²⁺ transference number increased from 0.47 to 0.75), and effectively excludes electroactive water molecules from the anode surface. As a result, the symmetric cells exhibit ultra-long cycling stability over 3500 h at 1 mA cm⁻², while Zn||Cu half-cells maintain a Coulombic efficiency of 99.65% for 900 cycles. ZnVO||HS-Cu@Zn full cell demonstrates exceptional cycling stability, achieving 2000 stable cycles at 5 A g⁻¹ with an average Coulombic efficiency of 99.8%.