Liver organoids, three-dimensional structures derived from stem cells or hepatic progenitors, have emerged as a transformative technology. Unlike traditional two-dimensional cultures or animal models, organoids faithfully recapitulate the complex architecture and functionality of native liver tissue. This review summarizes recent advancements in liver organoid technology, detailing their development, classification, and key applications.

Dissolved organic matter, a complex mixture of carbon-containing molecules found in soils, rivers, lakes, wetlands, and sediments, plays a central role in how carbon moves through the environment. It can feed microbes, bind pollutants, influence nutrient availability, and affect how much carbon is stored or released as carbon dioxide. Yet scientists are still working to understand why some dissolved organic matter is quickly consumed by microbes, while other portions persist much longer.

Researchers have developed a new biochar-based composite that can capture uranium from water while also converting part of it into a less toxic chemical form, offering a potential strategy for recovering uranium from seawater and supporting future nuclear energy resources.

Living tissues do not change through biology alone.

A new study reveals that reptile species richness peaks at mid-elevations and that woodland cover creates divergent habitat preferences across lizards, snakes, and chelonians.

Advanced composites are prized for being light yet strong, but designing them remains a slow and difficult task when both material layout and fiber direction must be optimized together. 

A research team has successfully removed the primary obstacle to post-silicon computing by using a room-temperature printing process to create a record-breaking electronic connection for atomic-thin materials.

By applying a 3.6-nanometer-thick "skin" of gallium oxide GaO_x between metal wires and a semiconductor sheet, the researchers achieved an electron mobility of 296 cm²·V⁻¹·s⁻¹ - the highest ever recorded for this type of material.

A systematic review suggest exercise may be a practical tool to help people quit smoking. Analyzing 59 randomized controlled trials involving 9,083 participants, researchers found that exercise modestly improved smoking abstinence, reduced cigarette consumption by about two cigarettes per day, and cut cravings after a single exercise session. The findings suggest exercise could be a safe, accessible, low-cost addition to smoking cessation support, although more research is needed on long-term effects and vaping.

Over the past decade, organoid research has boomed and revolutionized biomedicine, with wide industrial applications and regulatory recognition. However, comprehensive reviews on organoid-related regulations and IND-approved drugs remain insufficient. This article reviews relevant advances in regulations and IND applications, and discusses the prospects and limitations of organoid models.