Tetrandrine, a compound isolated from the root of a traditional Chinese medicine (TCM) Stephania tetrandra, has shown promise in combating Ebola virus infection in previous studies. Its precise mechanism of action, however, had remained unclear. Researchers from The Hong Kong Polytechnic University (PolyU) have discovered that tetrandrine works by blocking the transport of sphingosine – a lipid molecule essential for cellular signalling – and inhibiting the calcium channels. Their research has revealed the critical mechanism of tetrandrine for the first time, opening new avenues for drug discovery and disease treatment.

CHIKVdb is a comprehensive genomic database developed to address limitations in existing resources for chikungunya virus (CHIKV) surveillance and outbreak response. It integrates 8,193 nucleotide and 10,637 protein sequences from 99 countries over 40 years, accompanied by standardized metadata. The platform features an interactive web interface with tools for phylogenetic analysis, source tracing, SNP identification, and genotype identification, streamlining workflows for public health and research applications. Global analyses reveal spatiotemporal heterogeneity in CHIKV transmission, highlighting the predominance of ECSA and ECSA-IOL genotypes and the central role of human and mosquito hosts. CHIKVdb enhances genomic surveillance by providing curated data and analytical capabilities, supporting efforts in pandemic preparedness and targeted control strategies. The database is freely accessible at https://nmdc.cn/gcpathogen/chikv.

A review paper by scientists at the University of Oxford highlights recent advancements in SMTE, including innovations in scaffold design, cell sourcing, usage of external physicochemical cues, and bioreactor technologies.

The review paper, published on May. 15, 2025 in the journal Cyborg and Bionic Systems, presented the emerging synergies between SMTE and robotics, focusing on the use of robotic systems to enhance bioreactor performance and the development of biohybrid devices integrating engineered muscle tissue.

A research paper by scientists at Duke University proposed a novel sharp-edge acoustofluidic platform designed for rapid and effective sample preparation, coupled with sensitive detection of specific sEV populations based on their surface markers.

The new research paper, published on July. 17 in the journal Cyborg and Bionic Systems, presented an acoustofluidic technology which enables highly flexible, specific, and efficient capture and detection of circulating extracellular vesicles (sEVs) from small sample volumes. Its portability, low cost, and ease of use make it an ideal tool for point-of-care detection of sEV surface markers, while its modular design allows for one-step, high-throughput capture and detection of diverse sEV populations

An international team of researchers has reviewed the latest advances in multimodal artificial intelligence (AI) for cardiovascular diseases (CVD), highlighting its superior diagnostic accuracy, risk prediction, and therapeutic guidance compared with traditional single-data approaches. The review outlines how integrating imaging, genomics, electronic health records, and wearable data into unified AI models can enable earlier diagnosis, personalized therapy, and continuous remote monitoring, heralding a new era of precision cardiology.

A large-scale genetic study comparing Chinese and UK patients with hypertrophic cardiomyopathy (HCM) reveals significant ethnic differences in rare variant burden and specific mutations, highlighting the need for ancestry-aware genetic diagnostics and personalized medicine.

AlphaFold 3 (AF3), the latest AI model from Google DeepMind and Isomorphic Labs, can predict the structures and interactions of nearly all biomolecules with unprecedented accuracy, opening new avenues for drug design, vaccine development, and precision medicine.

Recently, a research team led by Professor Wenfeng Cong from China Agricultural University, in collaboration with Dr. Wopke van der Werf from Wageningen University & Research in the Netherlands, revealed the changing trends of dietary zinc intake among Chinese adults and the underlying reasons by analyzing data from China Health and Nutrition Surveys conducted between 2004 and 2011. The study covered 21,266 adults aged 18–50 from 9 provinces and 3 municipalities directly under the central government in China. The results showed that from 2004 to 2011, the average daily zinc intake of Chinese adults decreased from 11.1 to 9.89 mg, and the proportion of people with insufficient intake increased from 23% to 37%, a growth of more than 60%. Notably, this trend was prevalent across different income groups—although the zinc intake of high-income groups was consistently higher than that of low-income groups, zinc intake in all income strata showed a downward trend. The related paper has been published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2024584).

Relative weights analyses showed the neglect/interference/punishment domain contributed most significantly (28.78%) to behavior problems in preschool children with developmental disabilities.