This collection features articles on Supramoleular Interactions published in Supramolecular Materials. All articles are free to read and download.

Highlights

• Homoharringtonine (HHT) downregulates CCAAT/enhancer-binding protein alpha (CEBPA) expression.

• The homoharringtonine, daunorubicin, and cytarabine (HAD) induction regimen demonstrates efficacy in acute myeloid leukemia (AML) with CEBPA double mutations (CEBPAdm).

• The HAD regimen produces encouraging event-free survival (EFS) and relapse-free survival (RFS) in patients with CEBPAdm AML, both of which met the predetermined objectives.

Highlights

• Single-cell analysis defines the adverse diffuse large B-cell lymphoma tumor microenvironment (DLBCL TME) as a state of classical T-cell exhaustion rather than immune quiescence.

• A robust five-gene score (immune exhaustion-Related Prognostic Score, IERPS) independently predicts poor survival across multiple cohorts.

• IERPS exhibits clinical significance in individualized medicine for chimeric antigen receptor (CAR)-T cell therapy.

• IERPS dynamically tracks clinical response to the T-cell engager glofitamab.

Long-term fertilization enhances most functional groups. Manure and manure+NPK surpass NPK in enriching food web components. Manure and manure+NPK surpass NPK in enriching food web components. Manure and manure+NPK surpass NPK in enriching food web components.

Highlights

• Integrin alpha 3 (ITGA3) protein expression was detected in approximately 85% of breast cancer specimens by immunohistochemistry.

• ITGA3 expression was significantly higher in human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor(HR)-positive/HER2-negative breast cancer than in triple-negative breast cancer (TNBC).

• High ITGA3 protein expression was associated with shorter 5-year recurrence-free survival.

• ITGA3 alterations in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort were associated with worse relapse-free and overall survival.

• Integrin α3β1 represents a potential prognostic biomarker and therapeutic target warranting prospective validation.