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Updates every hour. Last Updated: 19-Dec-2025 18:11 ET (19-Dec-2025 23:11 GMT/UTC)
The functions and mechanisms of the cohesin complex in regulating the fate determinations of stem cells
ResearchConventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures chromatin topology to precisely coordinate enhancer-promoter interactions, which offers novel insights into fate decisions of hematopoietic stem cells, embryonic stem cells, and neural stem cells. This mechanisms provide significant applications for regenerative medicine and cancer therapy. Prof. Zuping He’s team at Hainan Medical University has reviewed multidimensional regulatory networks of the complex in ‘The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells’.
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- National Natural Science Foundation of China, Developmental Biology and Breeding, Research Team for Reproduction Health and Translational Medicine of Hunan Normal University, Hunan Provincial College Students’ Innovation and Entrepreneurship Training Program
Tracking frozen ground from orbit: Dynamic parameters unlock precision in soil monitoring
Journal of Remote SensingPeer-Reviewed Publication
Soil freeze–thaw (FT) cycles play a crucial role in land–atmosphere energy exchange and climate regulation, yet accurate global detection remains challenging.
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- Journal of Remote Sensing
Breakthrough 3D dynamic cell models revolutionize MASLD research
BMEF (BME Frontiers)Peer-Reviewed Publication
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- BME Frontiers
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- The project was partially funded by NHMRC APP2000647.
Elevated dickkopf 3 promotes abdominal aortic aneurysm formation via modulated phenotype switch of vascular smooth muscle cells
ResearchPeer-Reviewed Publication
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- Research
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- National Key Research and Development Program of China, National Natural Science Foundation of China, Key Science and Technology Project of Beijing Municipal Institutions, National Key Research and Development Program of China, Open Research Fund Program of Beijing National Research Center for Information Science and Technology