Brain extracellular space from an overlooked dimension to catalyst of a novel neuroscience paradigm
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Jun-2026 05:15 ET (29-Jun-2026 09:15 GMT/UTC)
A review paper by scientists at Peking University Third Hospital investigates underlying determinants of low translational success of central nervous system drugs and therapeutic devices, reviews the historical and technical bottlenecks that lead to the neglect of ECS research, and emphasizes its transformative potential in reshaping therapeutic strategies.
The review paper, published on Mar 4, 2026 in the journal Cyborg and Bionic Systems.
A new study reviews how machine learning (ML) is being used to help communities recover critical infrastructure after natural hazards such as earthquakes, floods, and hurricanes. The research synthesizes global studies and shows that ML can support recovery by characterizing recovery trends, predicting recovery times, and optimizing recovery schedules. The authors also identify key challenges, such as limited data availability, and outline future directions for building more resilient infrastructure systems using ML.
Professor Chao Zhang’s team at Zhujiang Hospital, Southern Medical University, has developed a novel DNA nanomachine–based drug delivery and release strategy aimed at overcoming chemoresistance in small cell lung cancer (SCLC). The team identified the PRMT1/SOX2 signaling axis as a key driver of chemotherapy resistance in SCLC and, based on this mechanism, designed a DNA nanomachine capable of temporally programmed drug release. By precisely targeting chemoresistant tumor cells, the nanomachine rapidly releases a stemness inhibitor followed by the sustained release of the chemotherapeutic agent cisplatin, thereby effectively reversing tumor stemness and significantly enhancing chemosensitivity. The related work, entitled “A DNA Nanomachine Modulates the Stemness-Associated Signaling Pathways for Overcoming Chemoresistance by Temporally Programming Drug Release,” was published in Research.
Neuroimaging analysis in brain disorders faces a persistent challenge: brain signals are complex and high-dimensional, while high-quality labeled datasets remain limited. This review article systematically examines how self-supervised learning can help address that gap by learning meaningful representations directly from unlabeled neuroimaging data. It covers major methodological families, including contrastive, generative, and hybrid generative-contrastive approaches, and discusses their applications in functional MRI, EEG, and multimodal brain network analysis.
The review argues that self-supervised learning offers more than annotation efficiency. It may enable more transferable and clinically useful representations for disease screening, diagnosis, and prognosis across heterogeneous datasets and disorders. At the same time, interpretability, data heterogeneity, missing modalities, and clinical validation remain major barriers. Future work will likely focus on stronger multimodal fusion, better cross-site generalization, and more clinically adaptable model design.