In situ pixel-scale magnetic programming 3D printing technology, pioneering a new era for multifunctional medical applications of soft miniature robots
ResearchPeer-Reviewed Publication
The treatment of gastrointestinal and urinary system diseases has long been plagued by limitations of traditional drug delivery methods, such as low drug concentration at target sites, lack of specificity in release, and short in vivo retention time, all of which result in suboptimal therapeutic efficacy. Magnetic microrobots, with their advantages of non-contact actuation, deep tissue penetration, and non-radiative operation, have emerged as ideal candidates for in vivo targeted drug delivery. However, existing manufacturing methods for magnetic robots have significant drawbacks: mold-assisted pre-deforming magnetization methods struggle to achieve complex deformations; emerging customizable fabrication techniques, such as nozzle magnetization during direct ink writing and laser-induced local remagnetization, can control the remnant magnetization of robot components to a certain extent but lack uniform and high-precision 3D magnetic fields, limiting the functional complexity and deformation accuracy of magnetic robots. To address these limitations, this study developed in-situ pixel-scale magnetic programming 3D printing technology, aiming to break through the bottlenecks of existing manufacturing techniques.
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- Research
- Funder
- National Key Research and Development Program of China, National Natural Science Foundation of China, Beijing Natural Science Foundation, Fundamental Research Funds for the Central Universities, the XPLORER PRIZE