Intervertebral disc degeneration (IDD) is a leading cause of low back pain. Conventional therapeutic strategies are limited by single-target intervention and poor clinical efficacy, highlighting the urgent demand for multifunctional nanotherapeutics that synergistically target the complex pathological environment of IDD. MnB-RLG, an interfacial electron-regulated multifunctional nanozyme, exerts synergistic therapeutic effects against IDD through metabolic-redox regulation, providing a potential disease-modifying approach for the clinical management of IDD.

Achieving high hardness and toughness simultaneously remains a major challenge in advanced structural ceramics. Silicon nitride (Si₃N₄) ceramics provide a promising platform because their α, β, and γ polymorphs exhibit complementary strengthening and toughening characteristics. However, differences in transformation kinetics and rapid volume shrinkage during phase transitions hinder the formation of uniform multiphase microstructures with strong interfacial bonding. Here, a novel phase-transition-regulated precipitation–densification strategy was developed to construct triphase Silicon nitride in-situ composite ceramics with synergistic mechanical properties. This approach provides a new pathway for overcoming the hardness–toughness trade-off and advancing high-performance structural ceramics for demanding engineering applications.

^99mTc-HMPAO leukocyte scintigraphy is an improved, lower-radiation method playing a critical role in early diagnosis and subsequent monitoring of the rare and serious disease of necrotizing external otitis (NEO). Results, though garnered through a small study, show high specificity and sensitivity for diagnosis and later monitoring of disease progression or recurrence.

Mammalian brain activity changes across an entire lifetime, from early development to aging and disease. A new review in Nano Research describes how implantable microelectronics may one day make it possible to record brain activity across the whole brain, over long periods of time, with single-cell and single-spike precision.