Re-purposing 5-nonyloxytryptamine and epirubicin as polysialic acid mimetics for protection from MPP+-induced cytotoxicity in human neuronal cells
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Jul-2025 08:10 ET (15-Jul-2025 12:10 GMT/UTC)
New research in JNCCN from The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center found socially vulnerable patients with metastatic pancreatic cancer were significantly less likely to receive key components of quality care and had poorer survival.
Cancer diagnoses traditionally require invasive or labor-intensive procedures such as tissue biopsies. Now, research published in ACS Central Science reveals a method that uses pulsed infrared light to identify molecular profiles in blood plasma that could indicate the presence of certain common cancers. In this proof-of-concept study, blood plasma from more than 2,000 people was analyzed to link molecular patterns to lung cancer, extrapolating a potential “cancer fingerprint.”
Researchers have found new compounds that could be used to treat a common breast cancer that can be resistant to hormone therapies, outlined in a paper published in the journal RSC Medicinal Chemistry finding two critical enzymes involved in the production of the hormone oestrogen —aromatase and steroid sulfatase—at the same time.
Results of study led by investigators at the Vall d'Hebron Institute of Oncology (VHIO) show convergent genetic adaptation under hypoxia (lack of oxygen) between populations living at high-altitude in the Himalayan region such as Tibetans and Sherpas, and the development of oxygen-starved cancer cells.
In recent years, chemotherapy-induced cardiovascular disease has emerged as a significant cause of mortality among cancer survivors. Anthracyclines, pivotal in treating cancers like breast cancer and leukemia, are indispensable in cancer therapy, yet their severe cardiotoxicity presents a formidable challenge. A recent review in Medicine Plus offers profound insights into anthracycline-induced cardiotoxicity (AIC), exploring its mechanisms and therapeutic strategies, contributing to safer oncological treatments in the future.
Recently, Pingping Zhu, Zhenzhen Chen, Qiankun He from Zhengzhou University and Xinrui Lv from Henan University published a review paper on MedComm-Oncology, which is titled "Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors". They comprehensively reviewed the recent progress in understanding and targeting of CSCs and their niche.