Mitophagy is a selective autophagic process responsible for removing damaged mitochondria. In a recent review, Chinese researchers explored the molecular mechanisms that govern mitophagy and its aberrant role in the onset and progression of breast cancer. It offers a detailed overview of the dual functions of mitophagy in breast cancer advancement, investigates the potential of mitophagy-related genes and proteins as biomarkers and therapeutic targets, and emphasizes the significance of mitophagy regulators in enhancing treatment outcomes.

The review by Professor Rui-Hua Xu’s team from Sun Yat-Sen University synthesizes pivotal clinical evidence to address a central challenge: while immunotherapy has revolutionized cancer care, its success varies dramatically across different gastrointestinal cancers. The authors introduce a practical "three-strata" framework that categorizes tumors based on their underlying immunobiology—from highly immunogenic to deeply immunosuppressive—and outlines distinct, optimized therapeutic strategies for each group, offering a clear roadmap for clinicians and researchers.

Canine cancer patients receiving a new form of immunotherapy lived longer or shorter depending on the composition of their microbiome, the community of organisms living in their gut.

Researchers at the Johns Hopkins Kimmel Cancer Center have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key metabolic enzyme known as spermine oxidase (SMOX).

Researchers at MUSC Hollings Cancer Center have developed an AI-based tool called BIOPREVENT that uses blood biomarkers and clinical data to predict serious complications after stem cell and bone marrow transplants months before symptoms appear. In a study of more than 1,300 transplant recipients, the tool outperformed standard clinical models, identifying patients at higher risk for chronic graft-versus-host disease and transplant-related death. By providing earlier, personalized risk information through a free web-based application, BIOPREVENT could support closer monitoring and future prevention strategies in transplant care.