We’re all familiar with the outward signs of aging, such as sagging skin or thinning hair. But many age-related changes start within our cells, even our DNA, which can wear and tear over time. One creature has a way to reverse this process, at least temporarily. A hamster-sized primate from Madagascar, the fat-tailed dwarf lemur can turn back the aging clock during its annual hibernation season, according to markers of cellular aging called telomeres.

A new national study led by American Cancer Society (ACS) and Harvard T.H. Chan School of Public Health researchers finds patients whose facility was impacted by a wildfire disaster during recovery from lung cancer surgery had longer length of stay (LOS) than similar patients treated at the same facility, but at times when no disaster occurred.

BUFFALO, NY - March 11, 2025 – A new editorial was published in Oncotarget, Volume 16, on March 10, 2025, titled “EXPOSOMES and GENES: The duo influencing CANCER initiation and progression."

Researchers from Tel Aviv University utilized CRISPR to cut a single gene from cancer cells of head and neck tumors – and successfully eliminated 50% of the tumors in model animals. 

Researchers at the Francis Crick Institute have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells.

Understanding the differences in the mutations that accumulate in our blood stem cells as we age is important to understand how and why blood cancers develop and hopefully how to intervene before the onset of clinical symptoms.

Neuroblastoma (NB), the most prevalent extracranial solid tumor among children, is characterized by a high rate of metastasis. The pathogenesis of NB with bone or bone marrow metastasis (NB-BBM) and its complex immune microenvironment remain poorly understood, posing challenges for effective risk prediction for BBM and limiting therapeutic strategies.

Medical researchers in Japan have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs. By analyzing cerebrospinal fluid collected pre-treatment, researchers at Kyushu University identified specific proteins associated with a damaging immune response that can affect the central nervous system after therapy. Their findings could make immunotherapy cancer treatment safer by helping doctors identify high-risk patients in advance, allowing early treatment or even prevention of this condition.