Major study evaluates effectiveness of cancer diagnosis pathway for patients with non-specific symptoms
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Jan-2026 15:11 ET (26-Jan-2026 20:11 GMT/UTC)
A major UK study, led by researchers at the University of Oxford’s Nuffield Department of Primary Care Health Sciences, Oxford University Hospitals NHS Foundation Trust, the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, and Oxford Cancer, has provided the most comprehensive analysis to date of a cancer diagnosis pathway for patients presenting with non-specific symptoms (NSS), such as unexplained weight loss or fatigue. These symptoms can indicate a wide range of conditions, from benign diseases to late-stage cancers, making timely and accurate diagnosis a significant challenge in primary care.
To improve treatment rates for these patients, UCSF researchers designed a CAR T cell therapy and combined it with an older class of diabetes drugs called thiazolidinediones, to enhance NECTIN4 expression and make tumor cells more susceptible to NECTIN4-CAR T therapy.
Researchers from the National University of Singapore and the National Cancer Centre Singapore have developed a hydrogel-based method to keep human lymph node tissue alive and functional outside the body for at least a week — significantly longer than existing approaches. By embedding tissue slices in a bioengineered gel that mimics the body’s natural environment, the system preserves the structure and immune functions of the lymph node, allowing scientists to observe real-time responses to cancer antigens and mRNA vaccines. The platform offers a more accurate and human-relevant alternative to preclinical models and could support the development of personalised immunotherapies and vaccines.
A University of Cambridge study of adult mammary gland development has revealed new genes involved in breastfeeding, and provided insights into how genetic changes may be associated with breastfeeding disorders and postpartum breast cancers.
OKLAHOMA CITY – University of Oklahoma Health Campus Ph.D. candidate Alex Arreola has earned a prestigious National Cancer Institute grant – one of only 15 awarded nationwide this year. He is the first trainee from OU Health Stephenson Cancer Center to receive the honor, which will support his doctoral and postdoctoral training in experimental oncology and pathology.