Scientific breakthrough: We can now halve the price of costly cancer drug
Peer-Reviewed Publication
Updates every hour. Last Updated: 27-Oct-2025 02:11 ET (27-Oct-2025 06:11 GMT/UTC)
The demand for the widely used cancer drug Taxol is increasing, but it’s difficult and expensive to produce because it hasn’t been possible to do it biosynthetically. Until now, that is. Researchers from the University of Copenhagen have cracked the last part of a code that science has struggled with for 30 years. The breakthrough could halve the price of the drug and make production far more sustainable.
Deep-penetration light-triggered pyroptosis based on nanomedicine for tumor precision therapy still remains challenging. Towards this goal, Scientist in China reported a supramolecular engineering strategy to construct Pt(IV)-coordinated supra-(carbon dots) with NIR-activated photocatalytic capacity to trigger tumor pyroptosis, thereby evoking anti-tumor immune responses to suppress distant tumor and prevent cancer metastasis. The finding will open new avenues for precision phototherapy in future clinical oncology by supramolecular-mediated nanomedicine with deep-penetration light triggered pyroptosis.
If you have cancer, you expect to see an oncologist, but if you have heart failure you may or may not see a cardiologist. According to research published in the European Heart Journal, only around three out of five heart failure patients see a cardiologist at least once a year. The study also shows that patients who do see a cardiologist once a year are around 24% less likely to die in the following year.
A research team from Sun Yat-sen University Sixth Affiliated Hospital has made a groundbreaking discovery in colorectal cancer (CRC) research, identifying a long noncoding RNA (lncRNA) named ESSENCE (EGF Signal Sensing CAD's Effect; ENST00000415336) as a critical regulator of tumor progression. The study reveals that ESSENCE stabilizes a key metabolic enzyme, CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase), to promote cancer growth and suppress ferroptosis. The findings also propose a novel combination therapy targeting ESSENCE-high tumors, offering new hope for precision treatment.
Albert Einstein College of Medicine has appointed Britta Will, Ph.D., associate professor of oncology, of medicine and of cell biology, and the Diane and Arthur B. Belfer Scholar in Cancer Research, as the permanent director of the Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine.
With mitochondrial DNA (mtDNA) base editing tools, this study controlled the nuclear background to investigate the causal effect of mtDNA mutations. Co-existence of wild-type and mutant mtDNA (heteroplasmy) in MT-ND5 was introduced. Enhanced oncogenic potential was confirmed with in vitro and in vivo assays. They reported compromised mitochondrial respiration and increased glycolytic activity, often termed as the Warburg effect following the mutations. By tracking cellular phenotypes during the MT-ND5 heteroplasmy decay, they reasoned that the increased glycolytic activity was to rescue NAD+ depreciation. Increased ROS level, genome instability, altered NAD+ epigenetics are the likely factors drove oncogenesis post MT-ND5 mutations.
A study published today in the Journal of Cancer Survivorship found that cancer survivors receiving high-cost immunotherapy treatments were more likely to face financial hardship, leading to increased instances of being unable to afford care and taking fewer medications due to cost.
The research, focusing on Medicare-enrolled patients, investigated the financial challenges faced by cancer survivors, particularly those receiving expensive immunotherapies.
“Although it’s well-known that many cancer patients experience financial hardship due to healthcare costs, there’s not much research available that specifically assesses the financial strain linked to immunotherapy treatments, particularly among Medicare enrollees,” said the study’s senior author Cathy Bradley, PhD, Dean of the Colorado School of Public Health on the University of Colorado Anschutz Medical Campus. “As more therapies are developed and the cost of drugs continues to increase, it’s important to determine if patients, even those who are insured, can afford out-of-pocket costs or if these costs are becoming a barrier to access life-saving treatment.”