The Southern California Environmental Health Sciences Center (SCEHSC) has received an $8 million grant from the National Institutes of Health (NIH) to advance research on the health effects of environmental exposures. SCEHSC, which is based at the Keck School of Medicine of USC and has been continuously funded by NIH for more than 30 years. The center has supported research on air pollution that has been highly influential in development of regulatory standards, on extreme heat and wildfires, per- and polyfluoroalkyl substances (PFAS) and on environmental effects on cardiorespiratory health, neurodevelopment and cognitive aging, kidney, liver and metabolic disease, and diabetes. The new grant ensures the center can continue backing these and other efforts through pilot funding, service cores providing expertise in exposure assessment, study design, biostatistics and data science, community engagement, research translation and science communication, and additional resources. Central to SCEHSC’s impact is its pilot program, which provides funding and support to help investigators turn promising ideas into established research programs. The program has generated a 30-to-1 return on its investments, with pilot funding helping researchers attract additional support, primarily from NIH. The new NIH funding will also allow SCEHSC to expand its work in two new areas in environmental health: artificial intelligence (AI) and cancer. SCEHSC is also expanding its work on environmental exposures linked to cancer in children and adults, in collaboration with the USC Norris Comprehensive Cancer Center.