Exosomes as double-edged swords: Bridging inflammation and cancer through molecular communication and therapeutic potential
Peer-Reviewed Publication
Updates every hour. Last Updated: 7-Jul-2025 12:10 ET (7-Jul-2025 16:10 GMT/UTC)
In a review published in Molecular Biomedicine, the authors summarized the impact of exosomes on the progression of diseases through their carried cargo, affecting the microenvironment in inflammatory diseases and cancer. Moreover, exosomes have great potential as diagnostic biomarkers, therapeutic drugs, and drug delivery carriers in inflammatory diseases and cancer.
A new paper published by researchers at Fox Chase Cancer Center highlights the case of a patient who was diagnosed with adenoid cystic carcinoma (ACC) after a molecular panel identified the presence of an atypical fusion gene. The case underscores the importance of molecular testing in correctly diagnosing certain cancers, said first author Shuanzeng “Sam” Wei, MD, PhD, an Associate Professor in the Department of Pathology and Medical Director of the Clinical Genomics Laboratory at Fox Chase. He said the team published their case study to raise awareness that the absence of the typical MYB/MYBL1 fusion genes does not rule out ACC and that the novel NFIB fusion gene can also be diagnostic.