Artificial intelligence in pathology enables a deeper understanding of cancer
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Updates every hour. Last Updated: 22-Jun-2026 13:15 ET (22-Jun-2026 17:15 GMT/UTC)
Researchers from University Hospital Cologne have developed an autonomous agent-based AI system called ‘SPARK’ that acts as a “digital brain” / publication in Nature Medicine
J. Craig Venter, the genomicist whose work redrew the architecture of modern biology, died on 29 April 2026 in San Diego at the age of 79, following complications from treatment of a recently diagnosed cancer. Brain Health, a new peer-reviewed journal launched today by Genomic Press, publishes in its inaugural issue a scientific tribute by Dr. Julio Licinio that foregrounds a part of Venter’s legacy that other obituaries have understandably treated as background: his earliest major methodological breakthrough emerged at the National Institute of Neurological Disorders and Stroke, where he pioneered the expressed sequence tag as a route to rapidly identifying brain-expressed genes. The tribute traces an arc from that neuroscience starting point through the first complete bacterial genome, the parallel pursuit of the human sequence, large-scale ocean metagenomics, and the construction of the first cell controlled by a chemically synthesized genome.
Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies globally, with long-term survival heavily hindered by tumor recurrence, metastasis, and therapy resistance driven by a subpopulation of cancer stem cells (CSCs). While immune checkpoint blockade has revolutionized cancer treatment, its efficacy as a monotherapy in CRC remains limited, largely due to CSC-mediated immune evasion and adaptive resistance.
Osteosarcoma (OS) is a highly aggressive primary bone malignancy characterized by rapid progression, a high propensity for metastasis, and chemoresistance, which together contribute to poor clinical outcomes.
Lung adenocarcinoma (LUAD) is a highly invasive cancer often diagnosed at an advanced stage, leading to a dismal prognosis with an overall survival rate of less than five years. While cancer stem cells (CSCs) are known to drive tumor progression by altering the tumor microenvironment (TME) through extracellular vesicles (EVs), their precise role in lipid metabolic reprogramming and ferroptosis resistance has largely remained unexplored.
A 2019 vaping-related health scare reshaped how many smokers view the risks of e-cigarettes – and those perceptions still linger today. New research from MUSC Hollings Cancer Center found that smokers came to see e-cigarettes as equally or more dangerous relative to combustible cigarettes, even after the true cause of the illness was identified, which may influence decisions about quitting or switching.
“That period really changed how people think about these products,” said lead researcher Tracy Smith, Ph.D., who co-leads the Hollings Cancer Prevention and Control Program. “Even after we learned more about what caused the illness, those perceptions didn’t fully reset.”