Osteosarcoma (OS) is a highly aggressive primary bone malignancy characterized by rapid progression, a high propensity for metastasis, and chemoresistance, which together contribute to poor clinical outcomes.

Lung adenocarcinoma (LUAD) is a highly invasive cancer often diagnosed at an advanced stage, leading to a dismal prognosis with an overall survival rate of less than five years. While cancer stem cells (CSCs) are known to drive tumor progression by altering the tumor microenvironment (TME) through extracellular vesicles (EVs), their precise role in lipid metabolic reprogramming and ferroptosis resistance has largely remained unexplored. 

A 2019 vaping-related health scare reshaped how many smokers view the risks of e-cigarettes – and those perceptions still linger today. New research from MUSC Hollings Cancer Center found that smokers came to see e-cigarettes as equally or more dangerous relative to combustible cigarettes, even after the true cause of the illness was identified, which may influence decisions about quitting or switching.

“That period really changed how people think about these products,” said lead researcher Tracy Smith, Ph.D., who co-leads the Hollings Cancer Prevention and Control Program. “Even after we learned more about what caused the illness, those perceptions didn’t fully reset.”

Low doses of the investigational medicinal product endoxifen reduce breast density to the same extent as the standard treatment tamoxifen, but without causing such troublesome side effects. This is shown by a new study from Karolinska Institutet published in the Journal of the National Cancer Institute. The results may have implications for future preventive treatment of breast cancer.