Melatonin application increases effectiveness of autologous ovarian tissue transplantation, study reveals
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Updates every hour. Last Updated: 22-Jun-2026 00:15 ET (22-Jun-2026 04:15 GMT/UTC)
Breast cancer remains a leading cause of malignancy-related mortality among women globally, with triple-negative breast cancer (TNBC) posing a significant clinical challenge due to its aggressive nature and early metastatic potential. Previous studies have implicated obesity in driving tumor progression, often associating it with diminished therapeutic responses and poor survival outcomes.
Gallbladder cancer (GBC) is the most common malignancy of the biliary system, often presenting with an abysmal prognosis due to its high propensity for early lymph node metastasis. While previous research has linked the reactivation of the highly conserved translation elongation factor eEF1A2 to poor outcomes in various cancers, its exact functional mechanisms driving GBC metastasis have remained elusive.
Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important defense systems is homologous recombination, a high-precision repair pathway that fixes broken DNA using key proteins such as RAD51 and CHK1. While therapies such as PARP inhibitors have successfully targeted this vulnerability, many tumors eventually regain their DNA repair ability and become resistant to treatment.
A research team led by Director MYUNG Kyungjae at the Center for Genomic Integrity within the Institute for Basic Science (IBS), in collaboration with LEE Joo-Yong (Chungnam University) has now uncovered a new strategy to overcome this resistance. Their findings show that cancer cells can be made vulnerable again—not by altering genetic mutations, but by destabilizing the DNA repair machinery itself.The responses to a national survey published today have revealed tunnel construction workers across Australia say they face significant exposure to silica dust, a hazardous dust that can cause incurable diseases like silicosis and lung cancer.