Uneven progress: Urban–rural gap widens in China’s fight against cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Dec-2025 20:11 ET (31-Dec-2025 01:11 GMT/UTC)
A surprising discovery reveals how a single protein helps cells decide when to make the building blocks of DNA. Researchers at CeMM, together with collaborators from the University of Oxford, have discovered that the enzyme NUDT5 acts not through its chemical activity, but as a physical “scaffold” that helps switch off a key metabolic pathway when purine levels are high. The study, published in Science (DOI 10.1126/science.adv4257), reveals a mechanism with implications for cancer treatment and inherited metabolic disorders.
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