Respiratory syncytial virus (RSV) exploits host proteases to enhance its replication efficiency; however, the precise mechanisms remain unclear. Through high-throughput screening, we identified four matrix metalloproteinase 9 (MMP-9) inhibitors (including JNJ0966 and doxycycline hyclate) that suppress RSV infection in vitro and in vivo.

FDA issued guidance on April 10, 2025 to phase out animal trials in favor of organoids and organ-on-a-chip systems. This pivotal move was swiftly followed by National Institutes of Health (NIH) on April 29, when it inaugurated the Office of Research Innovation, Validation, and Application (ORIVA).

Mastitis poses a significant economic challenge to the global dairy industry, causing approximately 35 billion USD in annual losses. Among its forms, subclinical mastitis (SM) is often overlooked due to the absence of obvious symptoms, yet it can lead to reduced milk production, increased treatment costs, and compromised dairy cow welfare.

As the semiconductor industry enters the era beyond Moore's Law, the drive for atomic-scale precision in surface planarization becomes more critical than ever. Recognizing this challenge, researchers from Tsinghua have reported a comprehensive review outlining the recent advances, inherent challenges, and future directions of atomic-scale chemical mechanical polishing (CMP). Their work synthesizes the interdisciplinary efforts necessary to transcend existing limitations in materials processing and manufacturing precision, paving the way toward the next frontier of semiconductor device fabrication.

This review provides systematic insights for the targeted design and process optimization of the next-generation atomic-scale CMP technology.

An interdisciplinary research team lead by Harbin Institute of Technology has developed a multifunctional biphasic bone scaffold featuring a "steel-cement" structure using eggshells waste. This scaffold integrates a rigid lattice (biosteel) with a bioactive hydrogel (biocement) loaded with composite drug-releasing particles, facilitating anti-infective and osteogenic functions. With adjustable mechanical properties, biodegradability, and intelligent responsiveness, this scaffold demonstrates significant potential for precise, sustainable, and dynamic bone regeneration.

This study not only demonstrates the high-value transformation of waste biological resources but also provides new ideas for advancing bone regeneration toward intelligent and personalized therapeutic paradigms.

In a significant stride towards cleaner water, researchers at the School of Resources and Environment, Northeast Agricultural University, Harbin, China, have developed a novel material that effectively removes harmful pollutants from water. Professors Jianhua Qu and Ying Zhang lead the team behind the study titled "Synthesis of Polyvinyl Chloride Modified Magnetic Hydrochar for Effective Removal of Pb(II) and Bisphenol A from Aqueous Phase: Performance and Mechanism Exploration." This innovative research introduces a powerful new tool in the fight against water pollution.

Acid rain from fossil fuel pollution may be quietly training soil bacteria to become longer-lived, more transmissible, and more deadly, according to a new study in the journal New Contaminants that tracks how a notorious foodborne pathogen rapidly evolved under simulated acid deposition.​​

Researchers have unveiled a promising new method that could transform how uranium is recovered from challenging wastewater streams. By combining a specially engineered covalent organic framework with an indirect electrochemical process, the approach delivers high efficiency, long term stability, and strong tolerance to chemically complex environments. The findings provide fresh insight into how advanced functional materials and optimized operating conditions can work together to support cleaner and more sustainable nuclear energy development.

A new study published in Nature on November 26 has shed light on the origins, population structures, and kinship systems of the people of Shimao—one of China's most significant late Neolithic settlements. Analyses of ancient DNA from individuals who inhabited the site reveal genetic links to southern settlements, while also providing evidence of male mass burials associated with human sacrifice.

The aroma of wine is shaped largely by volatile compounds originating from grape berries, among which β-damascenone is a major contributor to floral and fruity notes.