In a paper published in MedComm, a multicenter prospective cohort study combined with Mendelian randomization (MR) analysis reveals that preoperative cognitive impairment is independently associated with an increased risk of postoperative delirium (POD) in patients aged ≥75 undergoing elective noncardiac and noncranial surgeries. The study found the incidence of POD in patients with preoperative cognitive impairment was nearly two-fold higher than that in patients with normal cognitive function. Strikingly, Mini-Cog score is linearly and negatively correlated with POD risk, enabling quantitative prediction of postoperative delirium risk.

Transmission dynamics are complicated by mosquitoes' ability to carry multiple viruses simultaneously. For complex infections that may involve multiple viruses and pathogens, metagenomics next-generation sequencing (mNGS) technology is a more comprehensive approach. It offers in-depth reports for rapid and accurate detection.

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of liver cells accelerates fat accumulation, inflammation and fibrosis, while chronic steatosis in turn hastens hepatic decline. Up to 38 % of adults worldwide have MASLD, and prevalence, severity and mortality all rise with age. Ageing livers shrink by ~30 %, clear lipids and glucose less efficiently, and regenerate more slowly after injury. Lipid deposition is driven by falling β-oxidation, leptin resistance and the GPCPD1–glycerophosphocholine pathway; glucose intolerance emerges from insulin resistance linked to visceral obesity and telomere-p53 signalling. Senescent hepatocytes, endothelial cells, stellate cells and Kupffer macrophages each contribute distinct pathologies, but their shared secretion of the senescence-associated secretory phenotype (SASP) propagates damage throughout the organ.

A material design approach that introduces the asymmetric coordination structure in the single-metal region greatly improves the dipole polarization loss of the material at this site and directly improves the electromagnetic wave absorption properties.