Macrocycles serve as key building blocks for mechanically interlocked molecules. Incorporating novel macrocyclic motifs into interlocked topologies not only expands structural diversity but also unlocks emergent properties. This review summarizes mechanically interlocked molecules consisting of radially conjugated macrocycles, highlighting their innovative structural designs and synthetic approaches from a topological perspective.

Researchers have developed a high-vacuum annealing strategy to regulate the oxygen vacancy (O_v) concentration in RuO₂, thereby enabling the precise modulation of the atomic coordination structures of RuO₂. The optimized RuO_2-x catalyst exhibits exceptional oxygen evolution reaction (OER) performance, attributed to the synergistic effects between the metallic Ru-Ru and Ru-O moieties.

With the continuous development of drug delivery technology, natural polyphenol self-assembled drug delivery systems (DDS) have become a research focus due to their unique advantages. Polyphenols can not only serve as drugs themselves but also as components of self-assembled drug delivery systems, broadening their application in the field of drug delivery. This article reviews the mechanisms of interactions between polyphenols and between polyphenols and other molecules, and analyzes the process of constructing drug delivery systems with polyphenols. At the same time, it deeply explores the multiple functions of polyphenol self-assembled complexes in drug delivery, such as enhancing drug efficacy, achieving precise targeted delivery, and overcoming biological barriers, highlighting their great potential in enhancing drug efficacy and reducing side effects. In addition, several advanced characterization and preparation techniques are introduced and discussed, which will help to deeply understand and evaluate the structure and performance of polyphenol self-assembled delivery systems, promoting their further development. Finally, the challenges and future intelligent manufacturing strategies of polyphenol self-assembled complexes are summarized.

Immunosenescence, the age-related decline in immune function, significantly impacts the efficacy of immunotherapy in elderly cancer patients. A groundbreaking review published in Nano Research highlights how nanomedicine precisely target immunosenescence by remodeling the tumor microenvironment (TME), eliminating senescent cells, and mimicking immune cell functions, thereby reversing or ameliorating the aged TME to improve treatment and prognosis for elderly cancer patients. This interdisciplinary approach promises to overcome the limitations of current treatments and improve outcomes for older cancer patients.

Recently, Professor Shijian Zheng and Associate Professor Kaixiang Lei from Hebei University of Technology, in collaboration with Professor Lin Li and Dr. Xunzhu Zhou from Wenzhou University, published a research paper titled "Synergistic biphasic engineering and dual-site high-entropy doping enable stable sodium storage in layered oxide cathodes" in the journal Nano Research. In this study, a novel P2/O3 biphasic high-entropy oxide cathode material (Na_0.88K_0.02Ni_0.24Li_0.06Mg_0.07Fe_0.1Mn_0.41Ti_0.1Sn_0.02O₂, HEO) for sodium-ion batteries was successfully synthesized. By integrating biphasic engineering with a high-entropy strategy, this material effectively suppresses irreversible phase transitions, significantly enhances particle integrity and structural stability, and simultaneously improves the diffusion kinetics of Na⁺. Experimental results demonstrate that the cathode material maintains a high capacity retention of 82.68% after 1000 cycles, exhibiting its outstanding cycling stability.

Sulfide-based all-solid-state lithium metal batteries (ASSLMBs) are promising for high-energy-density and safe energy storage. But the poor compatibility of sulfide electrolytes with both high-voltage cathodes and lithium metal anodes hinders their practical application. Here, Professor Xie Jia's group from Huazhong University of Science and Technology discloses a fluorine-nitrogen synergistic interfacial engineering strategy by modifying Li5.5PS4.5Cl1.5 (LPSC) with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). The modified LPSC electrolyte shows a high ionic conductivity of 2.88 mS/cm. Moreover, LiTFSI induced dual-functional interphases, a fluorine-rich CEI (LiF/LixPOyFz) and a fluorine-nitrogen composite SEI (Li3N/LiF/LixPOyFz), contributing to high oxidation stability (LiNi0.8Co0.1Mn0.1O2//LiIn battery retains 107% capacity retention after 13000 cycles at 15 C) and excellent lithium dendrite inhibition ability (Li//Li: CCD 3.4 mA/cm2, stably cycling 2600 h at 0.5 mA/cm2). As a result, the LiNi0.8Co0.1Mn0.1O2//Li cell with modified electrolyte demonstrates 1000 stable cycles at a high cut-off voltage of 4.5 V and wide-temperature adaptability (-20~50 ℃). This work shows a facile and effective method for constructing long-life high-energy-density sulfide based ASSLMBs.

Researchers at Yale University have identified cytosolic phospholipase A2 (cPLA2) as a key driver of cartilage degeneration and chondrocyte senescence in osteoarthritis and intervertebral disc degeneration. Through genetic deletion and pharmacological inhibition using fexofenadine, they effectively suppressed inflammation, preserved cartilage integrity, and alleviated pain in preclinical models. The study positions cPLA2 as a promising therapeutic target and highlights fexofenadine, a widely available, FDA-approved drug, as a potential repurposed treatment for debilitating musculoskeletal disorders.