A mesoporous molecular sieve-based oral taste-masking agent with efficient shielding effect for oral administration of cetirizine
Peer-Reviewed Publication
Updates every hour. Last Updated: 17-Jan-2026 04:11 ET (17-Jan-2026 09:11 GMT/UTC)
The bad taste of the drug will seriously affect the patient 's medication compliance, after the mesoporous molecular sieve is loaded with the drug, it enters the channel, the amount of drug in contact with the taste buds was significantly reduced, and reduce the release rate of the drug, so that the bitterness is greatly reduced. In this paper, MCM-41 molecular sieve (MCM-41), MCM-48 molecular sieve (MCM-48)and hollow mesoporous molecular sieve (HMSS) molecular sieves were used as carriers to mask cetirizine for the first time, at the same time, it was compared with aspartame and β-cyclodextrin commonly used taste masking agents, and the drug-loaded complexes were characterized and analyzed by X-ray diffraction and Fourier Transform infrared spectroscopy, the results showed that except aspartame was only physically mixed, the other four materials were successfully adsorbed or included in the drug; among them, HMSS has a drug loading of up to 50 %, and the bitter taste of the drug is not obvious after drug loading. Its taste masking effect is obviously better than other materials, and it is expected to become a new type of high-efficiency taste masking agent.
Recent studies on carbon nanotube (CNT) field-effect transistors (FETs) and integrated circuits (ICs) have shown their potential in radiation tolerance. This work thoroughly examined the SEE of the CNT devices. Using a pulse laser as the irradiation source, the CNT FETs and static random-access memory (SRAM) exhibited an excellent radiation tolerance with a laser threshold energy of 5 nJ/pulse for SEE.
Scientists have harnessed sound waves to break a fundamental barrier in next-gen electronics. By using surface acoustic waves instead of traditional electricity to control 2D materials, they can now distinctly identify whether electrical current is carried by electrons or hole. This breakthrough unlocks a new dimension for designing ultra-high-density memory and brain-inspired neuromorphic chips with significantly more data states and tunable synaptic weights, enabling smarter, more compact devices.
With the growing demand for more efficient and sustainable chemical processes, single-atom catalysts (SACs) have become a research hotspot due to their high atomic utilization and unique catalytic performance. As a core characterization tool, XAFS (X-ray absorption fine structure) technology can deeply study the microscopic chemical environment of SACs, providing key data for catalyst design. This article is based on a review published in Nano Research, exploring the progress, challenges, and future prospects of XAFS in SACs research, aiming to provide readers with comprehensive scientific insights.
Immunometabolism have advanced the understanding of dynamic interplay between metabolic pathways and immune responses. Scientists identify a crucial enzyme that acts as a natural "off-switch" for lung inflammation. The study reveals that the enzyme ELOVL5, known for elongating fatty acid chains, promotes the resolution of inflammation by simultaneously inhibiting a major pro-inflammatory pathway and reshaping lipid metabolism. This dual mechanism offers a promising new target for treating inflammatory diseases.
Biliary atresia (BA) is a rare but life-threatening neonatal liver disorder marked by bile duct obstruction.
Primary central nervous system lymphoma (PCNSL) is a rare and highly aggressive lymphoma or tumor of the brain. While ventricular brain lymphoma is even rarer, its clinical characteristics and treatment strategies remain less explored. Now, researchers have evaluated the clinical features of PCNSL lesions involving the ventricles. They found that this rare tumor type shares key features with other brain lymphomas, suggesting a unified treatment approach.
A new review in Chinese Medical Journal highlights exosomes’ role in obstructive sleep apnea (OSA)-related diseases. OSA’s intermittent hypoxia alters exosome cargo, driving cellular dysfunction linked to cardiovascular issues, diabetes, neurodegeneration, and cancer, while exosomes also show therapeutic potential.
Flash memory is critical for data-centric systems. A novel floating-gate memory using Pt nanocrystals embedded in a h-BN/MoS2 van der Waals heterostructure combines ultrafast (20 ns) operational speed with retention time exceeding 105 s. Pt nanocrystals formed via rapid thermal annealing spatially isolate charges, suppressing leakage for stable operation. Configurable logic-in-memory circuits were realized based on the flash memory, demonstrating its potential for energy-efficient computing. This work was published in National Science Open (NSO).