Clear cell renal cell carcinoma (ccRCC) is characterized by frequent mutations in genes involved in chromatin remodeling and DNA damage repair. This review examines how essential genetic mutations in ccRCC impair DNA damage repair mechanisms and simultaneously modulate the tumor immune microenvironment. We discuss the interplay between genomic instability and immune response, highlighting how mutations in key genes such as VHL, PBRM1, and BAP1 create therapeutic vulnerabilities. Understanding these relationships may inform novel combination strategies targeting both DNA repair pathways and immune checkpoint mechanisms in ccRCC.

Published in Journal of Bioresources and Bioproducts, the review systematically summarizes recent advancements in multifunctional paper-based smart packaging. It highlights core modification strategies—internal additive incorporation, impregnation, coating, surface functionalization, and layer-by-layer assembly—that transform paper from passive protection into active regulation and intelligent sensing platforms. The authors discuss matrix-specific synergistic systems tailored to fresh produce and high-protein foods, while critically analyzing challenges including the recyclability paradox of high-performance coatings, unpredictable migration safety, and the scalability gap between laboratory innovation and industrial production.

A key challenge in cancer precision oncology is the limited ability of genomic analyses to accurately predict changes in protein expression or function, even though proteins serve as the main targets of numerous modern therapies. Bridging this gap necessitates precise quantification of proteins and their post-translational modifications (PTMs). Recent advances in mass spectrometry (MS)-based proteomics now enable large-scale, quantitative characterization of proteins and PTMs in tumor tissues. To link genomic aberrations to cancer phenotypes, the emerging field of proteogenomics integrates proteomic data, including PTMs, with genomic, epigenomic, and transcriptomic information. This comprehensive approach offers a deeper understanding of cancer biology at multiple levels. This review highlights recent advancements in MS-based proteomics, key discoveries in cancer proteogenomics, and the transformative potential of this field in decoding the complexities of cancer across diverse dimensions.

A research team led by Prof. MENG Guowen and Prof. HAN Fangming from the Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, in collaboration with Prof. WEI Bingqing from the University of Delaware, has developed a highly crystalline three-dimensional graphitic carbon tube grid (3D-GCTG) that significantly improves the performance of filtering supercapacitors with thick electrodes.

Researchers from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), together with collaborators from Ningbo Institute of Materials Technology & Engineering, CAS, and Eastern Institute of Technology, have developed a low-noise magnetic sensor that retains high sensitivity, thereby enabling improved weak-field detection.

A research team led by Prof. HUANG Qing from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, in collaboration with the Shanghai Institute of Optics and Fine Mechanics and Shandong University, has found that nanosecond laser-driven proton FLASH radiotherapy can maintain its cancer-killing effect while reducing damage to normal cells.

A research team has developed BloomNet, an interpretable deep-learning framework that forecasts harmful algal blooms at hourly resolution up to 72 hours ahead while also showing how risk changes over time. 

An international research team has discovered the earliest known siphuncle-bearing cephalopod from the early Cambrian of South China, providing new insights into the group’s early origin and evolutionary history.

We have used a rapid, solvent-free pulse laser ablation in liquids technique to create sulfur-defect rich zinc indium sulfide (ZnIn₂S₄) nanosheets. These engineered defects act as super-active sites, dramatically improving the material's ability to convert carbon dioxide (CO₂) into carbon monoxide (CO) using visible light. The optimized photocatalyst shows a 15-fold increase in performance and high stability, offering a promising new pathway for clean fuel production and carbon capture