CuAu alloys with tailored compositions were integrated onto copper foam by a simple one-step electrodeposition method. The optimized Cu_0.25Au_0.75 catalyst exhibited rather excellent performance for the electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) via a one-electron dehydrogenation pathway. The improved catalytic activity could be attributed to the alloying-induced charge redistribution that modulates the d-band centers, thereby steering surface adsorption behaviors to balance HMF adsorption and HMFCA desorption, ensuring active site availability for the selective production of 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) and simultaneous anodic hydrogen evolution.

With the growing demand for marine exploration and environmental monitoring, underwater sensing technology faces severe challenges due to high humidity and the need for simultaneous detection of multiple physical parameters, such as temperature and pressure. Traditional underwater sensors typically rely on combinations of various functional materials to achieve dual-mode temperature–pressure detection, often requiring additional waterproof encapsulation, which complicates system integration. Achieving dual-mode temperature–pressure detection within a single material underwater remains particularly challenging. Herein, a waterproof dual-mode sensor based on Bi₂Se₃/carbon paper (CP) composite films is developed by electrochemically depositing pyramid-interface-structured Bi₂Se₃ layers on both sides of a flexible CP substrate. The film exhibits enhanced thermoelectric properties, with a power factor of 106.0 μW m⁻¹ K⁻² (9 times that of CP). Sensors constructed from vertically stacked pyramid-interface-structured films enable high-precision detection of temperature and pressure underwater, featuring a temperature-sensing response time of 0.9 s and a pressure sensitivity of 0.94% kPa⁻¹, while allowing synchronous decoupling of the two signals. Moreover, the sensor exhibits excellent hydrophobicity, with a contact angle of 143.7°, along with robust stability, overcoming key limitations for underwater applications. This advance in flexible underwater sensing technology offers a reliable strategy for underwater human–machine interaction and monitoring.

A new Perspective in Science Bulletin argues that AI tools for intracranial aneurysm detection should be evaluated beyond test-set accuracy. The authors propose a four-stage pathway covering lesion-level validation, reader performance, prospective implementation and post-deployment surveillance to assess whether AI can deliver real clinical benefit.

Monitoring COVID-19 NAbs dynamics remains dissolved as the lack of analytical strategies deployable in most practice, as stably remaining protein activity seems particularly difficult. We engineer selenium nanoparticles for LFIA that preserves protein activity and enhances stability. NAbs levels decrease with age and over time after infection, and they drop sharply with neurological and hematological diseases according to 1,328 samples. Our work provides a reliable and universally platform for next-generation point-of-care immunity monitoring and vaccine evaluation.

Anti-angiogenic therapies targeting VEGF signaling have limited clinical efficacy due to inevitable resistance. Researchers constructed a pancancer single-cell atlas of 1.24 million cells across 13 cancer types, revealing that pericytes (PCs) and PC-derived PGF/ANGPT2 are more prominent pro-angiogenic regulators than the classical VEGFA-centric model. Tumor-educated MCAM+ immature PCs (imPCs) were identified as the primary source of PGF/ANGPT2, driving alternative angiogenesis and anti-VEGFR resistance. Combining anti-VEGFR with MCAM-targeting antibody-drug conjugates achieved superior tumor control through dual EC/PC inhibition.

This review summarizes recent advances in wearable uric acid sensors, covering electrochemical and optical detection mechanisms, performance-enhancement strategies, device integration, and emerging applications. It highlights progress in sensitivity, selectivity, anti-fouling performance, self-calibration, and user comfort, while identifying persistent challenges in long-term stability, interference resistance, multimodal monitoring, clinical validation, data security, and commercialization. Future directions emphasize intelligent, sustainable, and personalized sensing platforms.

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with variable responses to radiotherapy. Identifying reliable biomarkers to predict treatment response remains an urgent clinical need. This study investigated secretory leukocyte peptidase inhibitor (SLPI) as a dynamic biomarker for radiotherapy response in ESCC. We found that SLPI expression correlated with treatment outcomes and may serve as a prognostic indicator for ESCC patients undergoing radiotherapy. These findings could help guide personalized treatment decisions and improve outcomes for ESCC patients.

Patients with inflammatory bowel disease (IBD) receiving immunosuppressive therapy face increased risks of infections, including hepatitis B virus (HBV) reactivation. This nationwide real-world study investigated the incidence and risk factors of HBV infection or reactivation and HBV-related liver dysfunction in Chinese IBD patients treated with infliximab. Our findings provide important insights for HBV screening and prophylactic antiviral therapy in this vulnerable population. The study emphasizes the need for careful monitoring and management of HBV status in IBD patients initiating biologic therapy.

The brain and body interact bidirectionally through complex neural, endocrine, immune, and metabolic pathways. Systemic diseases can affect brain structure and function, while brain disorders can influence peripheral organ systems. This review surveys recent neuroimaging studies that reveal disease-specific brain alterations across multiple systemic conditions, including cardiovascular, metabolic, autoimmune, and infectious diseases. We highlight common and distinct patterns of brain involvement and discuss the potential of imaging biomarkers for early diagnosis and therapeutic monitoring. Advanced imaging techniques provide unprecedented insights into brain-body interactions in health and disease.

Muscle and bone, key tissues that maintain the body's structure and function, are closely connected both anatomically and physiologically. Growing evidence suggests that vascular dysfunction serves as a critical link between sarcopenia and osteoporosis. This review summarizes the structural and functional interactions between the musculoskeletal and vascular systems, examines shared mechanisms underlying sarcopenia and osteoporosis, and discusses potential therapeutic strategies targeting vascular health to mitigate both conditions. The crosstalk between muscle-derived and bone-derived factors, mediated by the vascular system, offers new insights for understanding and treating these age-related conditions.