Myocardial ischemia/reperfusion injury (MI/RI) remains a major therapeutic challenge in acute myocardial infarction due to the lack of effective treatment options. Although mesenchymal stromal cells (MSCs) and their derivatives have shown promise in cardiac repair, their clinical translation is limited by poor delivery efficiency and reduced bioactivity. In this study, researchers developed nanoscale artificial cell-derived vesicles (Rg1-ACDVs) via mechano-extrusion of MSCs preconditioned with ginsenoside Rg1, a bioactive phytochemical. Compared to conventional extracellular vesicles (Rg1-EVs) and unprimed ACDVs, Rg1-ACDVs demonstrated superior therapeutic performance by promoting cell cycle progression and facilitating DNA damage repair, as revealed by multi-omics analyses. Functional assays confirmed their dual ability to scavenge reactive oxygen species (ROS) and safeguard genomic stability in both in vitro and in vivo models. This work underscores the synergistic potential of phytochemical priming and nanoscale bioengineering, establishing Rg1-ACDVs as a scalable and effective platform for advancing MI/RI therapy toward clinical application.

Significant relationship between vagus nerve and bone remodeling was identified through artificial intelligence (AI)-based knowledge mining. Iron oxide nanoparticles incorporated injectable hydrogels (termed M-Gels) were applied to rats' left neck vagus nerves, showing at least 20-week retention. Magnetic vagus nerve stimulation (mVNS) at 20 Hz twice daily for 16 weeks enhanced bone metabolism. AI analysis identified gut microbiota as a contributing factor, highlighting mVNS's potential for osteoporosis treatment.

The direct synthesis of semi-conductive quantum dot (QD) inks coordinated by inorganic ions in polar phases presents potential advantages such as low cost and scalability, making it an ideal approach for realizing QDs-based optoelectronic applications. However, the weak repulsive forces between QDs coordinated by inorganic ions can easily lead to agglomeration, significantly limiting size control during the synthesis process. Distinct from the traditional high-temperature injection and low-temperature growth strategy used in the synthesis of QDs with long-chain organic ligands, we discover that low-temperature injection nucleation and high-temperature growth is an effective strategy to achieve controllable tuning of reactive monomers and ligand ions in the direct synthesis system of inorganic ion-liganded QD inks, which in turn realizes the scalable, low-cost, and direct synthesis of uniform and size-tunable short-wavelength infrared (SWIR) PbS QD inks. The yield of single synthesis can be more than 10 g. Compared with the traditional ligand exchange method, the yield is improved by nearly 3 times and the cost is reduced to 7 times. Finally, the solar cell devices fabricated using these PbS SWIR QD inks achieved a photovoltaic conversion efficiency of approaching 9%, confirming the excellent optoelectronic performance of the synthesized PbS QD materials.

In photodetection systems, the ability to simultaneously measure light intensity, wavelength, and polarization is critical for advanced optical applications. A groundbreaking study introduces a novel photodetector leveraging halide perovskites, which uniquely combine electro-optic modulation with polarization-sensitive detection. By utilizing ultrafine nanoripples and micron-sized crystals in perovskite materials, this device achieves precise polarization response and electro-optic modulation. These properties, enhanced by the material’s superior optoelectronic performance, enable multidimensional polarization current generation and visualization key advancements for integrated optical systems. The innovation holds promise for applications in machine learning-driven optical technologies and compact photonic devices, marking a significant step toward multifunctional, high-efficiency optoelectronics.

The bad taste of the drug will seriously affect the patient 's medication compliance, after the mesoporous molecular sieve is loaded with the drug, it enters the channel, the amount of drug in contact with the taste buds was significantly reduced, and reduce the release rate of the drug, so that the bitterness is greatly reduced. In this paper, MCM-41 molecular sieve (MCM-41), MCM-48 molecular sieve (MCM-48)and hollow mesoporous molecular sieve (HMSS) molecular sieves were used as carriers to mask cetirizine for the first time, at the same time, it was compared with aspartame and β-cyclodextrin commonly used taste masking agents, and the drug-loaded complexes were characterized and analyzed by X-ray diffraction and Fourier Transform infrared spectroscopy, the results showed that except aspartame was only physically mixed, the other four materials were successfully adsorbed or included in the drug; among them, HMSS has a drug loading of up to 50 %, and the bitter taste of the drug is not obvious after drug loading. Its taste masking effect is obviously better than other materials, and it is expected to become a new type of high-efficiency taste masking agent.

Recent studies on carbon nanotube (CNT) field-effect transistors (FETs) and integrated circuits (ICs) have shown their potential in radiation tolerance. This work thoroughly examined the SEE of the CNT devices. Using a pulse laser as the irradiation source, the CNT FETs and static random-access memory (SRAM) exhibited an excellent radiation tolerance with a laser threshold energy of 5 nJ/pulse for SEE.

With the growing demand for more efficient and sustainable chemical processes, single-atom catalysts (SACs) have become a research hotspot due to their high atomic utilization and unique catalytic performance. As a core characterization tool, XAFS (X-ray absorption fine structure) technology can deeply study the microscopic chemical environment of SACs, providing key data for catalyst design. This article is based on a review published in Nano Research, exploring the progress, challenges, and future prospects of XAFS in SACs research, aiming to provide readers with comprehensive scientific insights.

Immunometabolism have advanced the understanding of dynamic interplay between metabolic pathways and immune responses. Scientists identify a crucial enzyme that acts as a natural "off-switch" for lung inflammation. The study reveals that the enzyme ELOVL5, known for elongating fatty acid chains, promotes the resolution of inflammation by simultaneously inhibiting a major pro-inflammatory pathway and reshaping lipid metabolism. This dual mechanism offers a promising new target for treating inflammatory diseases.