A novel interpenetrated RuO₂/Co₃O₄ heterostructure catalyst is developed, which synergistically couples the traditional adsorbate evolution mechanism (AEM) with the more efficient oxide pathway mechanism (OPM) for acidic oxygen evolution, achieving exceptional activity and stability that far surpass commercial RuO₂.

This paper clarified the antecedents, attributes, consequences, and empirical referents of safe care that may contribute to safer care and help healthcare professionals ensure patient safety.

Noninvasive detection of ultra-weak biomagnetic signals is crucial for modern biosensing, but conventional magnetic sensors are fundamentally limited by intrinsic noise. Orthogonal fluxgates (OFGs) enable high signal-to-noise-ratio detection of weak magnetic fields, yet their performance is still constrained by intrinsic 1/f noise and Barkhausen-related magnetic fluctuations. This study reports a low-noise orthogonal fluxgate in which a newly designed magnetic core and circuit mitigate existing noise limitations. The CoP/Ag composite core, featuring an amorphous-nanocrystalline dual phase, is associated with reduced low-frequency magnetic loss and improved noise performance. When integrated with a closed-loop feedback, the sensor achieves a noise floor of 8 pT/√Hz at 1 Hz. The sensor enables reliable detection of ultralow-concentration magnetic-bead signals. Alpha-fetoprotein (AFP) was used as a model biomarker in an immunomagnetic bead assay, yielding a linear response from 50 fg mL⁻¹ to 100 ng mL⁻¹ and a detection limit of 50 fg mL⁻¹, which compares favorably with representative reported AFP magnetic biosensors. OFGs demonstrate strong prospects in biosensing, geomagnetic measurements, and weak field detection.

Spinal muscular atrophy (SMA) is a severe neuromuscular disease caused by insufficient SMN protein, yet the critical downstream mechanisms underlying its pathogenesis remain unclear. We previously identified that splicing of the conserved minor intron of Pcyt2 (Phosphocholine cytidylyltransferase 2) depends on sufficient SMN protein. Here, we reveal that simply replacing the minor intron of Pcyt2 with a major intron is sufficient to reverse SMA-associated phenotypes. Based on our discovery that Pcyt2 is specifically expressed in certain neuroglial subtypes, we further show that restoring Pcyt2 in these subtypes significantly alleviates SMA-associated phenotypes in both Drosophila and mouse models. These findings identify Pcyt2 minor intron mis-splicing as a key driver of SMA, offering opportunities for new therapeutic and diagnostic strategies.

A new study introduces a factor graph optimization (FGO) framework for integrated Global Navigation Satellite System (GNSS)/Low Earth Orbit (LEO) precise point positioning (PPP). 

Circadian rhythms influence not only sleep and metabolism but also the ability of cancer cells to invade, survive in blood, and colonize distant organs.