Controlled rotation of single cells is essential for three-dimensional imaging and mechanobiology studies. Researchers at The University of Texas at Austin have developed an opto-thermo-osmotic platform that enables programmable rotation of both spherical particles and living cells along arbitrary axes. By dynamically reconfiguring laser patterns, the system achieves real-time switching between major-axis and minor-axis rotation modes, providing a versatile tool for label-free cellular imaging and manipulation.

Researchers have developed a thin-film lithium niobate integrated photonic receiver for dual-band radar, integrating electro-optic modulation and microwave demultiplexing on a single chip. Published in PhotoniX Synergy, the work combines integrated dual-band signal processing with coherent fusion to enable a 12-GHz equivalent bandwidth and a 1.27-cm ranging resolution, providing a highly integrated pathway toward microwave photonic radar systems.

In 287 Han Chinese adults with HIV-1, UGT1A1*6 was significantly associated with higher dolutegravir (DTG) trough concentrations, with homozygous carriers showing the strongest effect. Compound UGT1A1*6/*60 and UGT1A1*6/*28/*60 genotypes and low body weight were independent risk factors for elevated DTG levels. No significant associations were found between DTG trough concentrations and viral suppression or adverse effects. 

Solid tumors resist CAR cell therapy through antigen heterogeneity, poor infiltration, and an immunosuppressive microenvironment. A new review argues that oncolytic viruses and CAR cells should be co-designed as an integrated, self-amplifying therapeutic system rather than simply combined. The authors describe how oncolytic viruses can install new targets, remodel the tumor microenvironment, and deliver local immune support, outlining engineering strategies, translational challenges, and future directions for next-generation solid tumor immunotherapy.