Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Jan-2026 05:11 ET (14-Jan-2026 10:11 GMT/UTC)
Collagenase-like protease (Clp) enhances the toxic effect of Streptococcus suis serotype 2 (SS2). Clp increases the permeability of the blood–brain barrier by disrupting tight junctions and inducing apoptosis of brain endothelial cells. Clp triggers brain endothelial cell apoptosis through cell receptor ligand apoptosis and mitochondrial apoptosis pathways, partially dependent on its enzyme activity.
With the increasing acceptance of blastocyst transfer technologies, more attention is being paid to the selection of blastocysts during the transplant cycle. However, few studies have investigated the relationship between blastocyst quality and perinatal outcomes in single frozen-thawed blastocyst transfer (SFBT) cycles. The aim of this study was to focus solely on the blastocyst and investigate the association between embryo morphological grading and perinatal outcomes in an SFBT cycle.
To analyze the clinical characteristics, diagnostic challenges, treatment strategies, and long-term outcomes of ovarian leiomyomas through a 20-year retrospective study, aiming to improve awareness and management of this rare tumor. This single-center retrospective study included 39 cases of ovarian leiomyomas confirmed by histopathology and immunohistochemistry between January 2003 and December 2023 at the Obstetrics and Gynecology Hospital affiliated with Fudan University. Clinical, imaging, surgical, and follow-up data were systematically reviewed. Pathological criteria, including mitotic index and immunohistochemical markers, were used for tumor classification.
Obsessive-compulsive disorder (OCD) is classified by the World Health Organization as 1 of the 10 most disabling conditions. However, nationally representative epidemiological data on OCD are not yet available in China. To investigate the prevalence, comorbidity, role impairment and healthcare utilisation of OCD in China.
Aqueous zinc metal batteries (AZMBs) face significant challenges in achieving reversibility and cycling stability, primarily due to hydrogen evolution reactions (HER) and zinc dendrite growth. In this study, by employing carefully designed cells that approximate the structural characteristics of practical batteries, we revisit this widely held view through in-operando X-ray radiography to examine zinc dendrite formation and HER under near-practical operating conditions. While conventional understanding emphasizes the severity of these processes, our findings suggest that zinc dendrites and HER are noticeably less pronounced in dense, real-operation configurations compared to modified cells, possibly due to a more uniform electric field and the suppression of triple-phase boundaries. This study indicates that other components, such as degradation at the cathode current collector interface and configuration mismatches within the full cell, may also represent important barriers to the practical application of AZMBs, particularly during the early stages of electrodeposition.
A research team has uncovered a significant regulatory mechanism that enhances the jujube tree's defense against phytoplasma infections.
This paper elucidates the ecological context of two theropod dinosaurs of differing body sizes inhabiting the lakeshore region of Otog Banner, Inner Mongolia. The larger theropod exhibited a walking gait characterized by relatively short stride lengths, whereas the medium-sized theropod demonstrated a digitigrade posture indicative of rapid locomotion, achieving speeds up to 45 km/h. This represents the highest recorded speed among theropod dinosaur trackways from the Cretaceous period worldwide to date. Furthermore, these findings provide critical empirical evidence for advancing the understanding of the maximal locomotive capabilities of medium-sized theropods.The results were published as the cover paper in the 11th issue of Science China: Earth Sciences for 2025.
The proliferation of 5G communication technology and the miniaturization of electronic devices have made protection against human electromagnetic radiation an urgent global public health issue. Concurrently, intensifying great power arms races are driving electromagnetic warfare environments towards full-spectrum capabilities and intelligentization. Microwave (300 MHz–300 GHz) and terahertz wave (0.1–10 THz) technologies, as core frequency bands in electromagnetic spectrum engineering, have deeply penetrated critical fields such as communications, military, healthcare, and industrial inspection. Consequently, electromagnetic wave absorption and shielding have become imperative problems to solve. However, traditional absorbing materials face numerous challenges, such as singular loss mechanisms, a lack of adaptive cross-band regulation capability, and excessive thickness. These limitations severely restrict their application in complex electromagnetic compatibility scenarios.