Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity.

Winter arrives with shorter days, colder mornings, and a natural drop in energy. Many men start to feel small physical changes during this season, such as slower digestion, disrupted bowel habits, or a weaker urine stream. These winter symptoms should not be neglected, as some of them are on the checklist of potential cancer symptoms. Advanced genetic testing is reshaping precision oncology, not only for early screening but also for precision treatment. High-throughput sequencing technology-based cancer discovery testing is now helping doctors understand the personal genetic drivers of disease and provide guidance for the most effective treatment solutions, leading to better outcomes.

Researchers at Beijing Tiantan Hospital analyzed 101 glioma cases involving the brain’s motor pathway and found that one-third of patients developed permanent paralysis after surgery. High tumor grade, pre-operative motor deficits, and larger tumor volume were key predictors. The work underscores the need for precise imaging and careful surgical planning to maximize survival while safeguarding motor function.

Alzheimer’s disease (AD) imposes a substantial clinical and societal burden, yet currently approved symptomatic therapies do not modify the underlying disease biology. Recently, three anti-amyloid monoclonal antibodies (aducanumab, lecanemab, and donanemab) have demonstrated robust amyloid clearance. Their clinical effects are statistically significant but modest, underscoring the need for broader, biologically informed strategies. Guided by the 2024 Alzheimer’s association ATNIVS biomarker framework, a team form Xuanwu Hospital, Capital Medical University synthesizes disease-modifying therapies (DMTs) targeting amyloid (A), tau (T), neurodegeneration (N), inflammation (I), vascular injury (V), and α-synuclein (S), summarizing the candidate therapies for each target, explain the mechanisms of action and pivotal clinical trial results. The review is currently published on the journal Medicine Plus.

Researchers report a molecular design strategy for high-voltage organic cathodes in aluminum batteries. By constructing a sulfur-heterocyclic polymer with weak electron-donating effect and super-crosslinked sites, the cathode achieves a high voltage of ~1.7 V and a high capacity of 150 mAh g⁻¹. The designed organic cathode achieves a record 255 Wh kg⁻¹ energy density, breaking the upper limit of conventional graphite cathodes (~200 Wh kg⁻¹).

While unitized regenerative fuel cells (URFCs) are promising for renewable energy storage, their efficient operation requires simultaneous water management and gas transport, which is challenging from the standpoint of water management. Herein, a novel approach is introduced for examining the alignment hydrophilic pattern of a Ti porous transport layer (PTL) with the flow field of a bipolar plate (BP). UV/ozone patterning and is employed to impart amphiphilic characteristics to the hydrophobic silanized Ti PTL, enabling low-cost and scalable fabrication. The hydrophilic pattern and its alignment with the BP are comprehensively analyzed using electrochemical methods and computational simulations. Notably, the serpentine-patterned (SP) Ti PTL, wherein the hydrophilic channel is directly aligned with the serpentine flow field of the BP, effectively enhances oxygen removal in the water electrolyzer (WE) mode and mitigates water flooding in the fuel cell (FC) mode, ensuring uninterrupted water and gas flow. Further, URFCs with SP configuration exhibit remarkable performance in the WE and FC modes, achieving a significantly improved round-trip efficiency of 25.7% at 2 A cm⁻².

Weyl semimetals, hosting chiral Weyl fermions with momentum-locked spin textures, offer a promising platform for developing quantum information technologies based on chiral degrees of freedom. Recently, Professor Dong Sun’s group at Peking University demonstrated selective injection of chiral Weyl fermions in the magnetic Weyl semimetal Co₃Sn₂S₂ using circularly polarized mid-infrared light through a third-order nonlinear optical process under a static electric field. By tuning both the external electric field and the ferromagnetic order, they achieved flexible and reversible control of chiral optical responses. Helicity-dependent photocurrent measurements revealed strong mid-infrared chiral signals, including wavelength-dependent sign reversals associated with imbalanced excitation of oppositely polarized Weyl fermions, confirming their Weyl-cone origin. This work highlights the exceptional tunability of magnetic Weyl semimetals for chiral regulation and establishes a foundation for future quantum devices based on chiral information carriers. The study was published in National Science Review (2025), with the School of Physics at Peking University as the first affiliation; Zipu Fan is the first author, and Professors Dong Sun, Jinluo Cheng, and Enke Liu are the corresponding authors.