Although Alzheimer's disease is considered an illness of old age, a new study shows blood biomarkers can identify the risk for early-onset Alzheimer's, which develops before the age of 65, as early as age 24.Early detection and prevention remain crucial in managing early-onset Alzheimer's. With modern research and new technologies, doctors can now identify warning signs years, even decades, before symptoms appear.

Optical Torque serves as a core technology for the manipulation of micro- and nanoscale rotors and the investigation of cellular mechanics, playing a critical role in advancing biomedical research, precision measurement, and advanced manufacturing.

Gastric cancer remains one of the world’s leading causes of cancer deaths, yet the molecular steps driving its onset remain elusive.

Understanding the physics of nonlinear optical response in subwavelength plasmonic resonators is of fundamental importance for controlling light with light at the nanoscale. Researchers at City University of Hong Kong have now harnessed magnetic dipole resonances in an ultra-compact plasmonic nanocavity to achieve Lorentz-force-driven second-harmonic generation. This work suggests a novel mechanism beyond conventional dipole electric field enhancement, and it provides a versatile framework for nonlinear nanophotonics, paving the way for developing efficient nonlinear devices.

For brain tumors, radiology reports provide essential imaging perspectives while pathology reports deliver microscopic confirmation, but each type of report typically requires domain experts to interpret separately. This separation can make it difficult to form a consistent basis for diagnosis and to reliably link findings to patient survival. Leveraging the integrative capabilities of large language models (LLMs), both sources can now be analyzed within a unified framework, reducing fragmentation and improving the accuracy of diagnostic classification and survival prediction.

To address this, a team led by Dr. Zhuoqi Ma (1^st author) and Dr. Zhicheng Jiao (corresponding) from the Department of Radiology at Brown University and Brown University Health developed a large language model (LLM)-based pipeline that integrates radiology and pathology reports within a unified framework. By leveraging the integrative capabilities of LLMs, both sources can be analyzed together and improving the accuracy of diagnostic classification and survival prediction. Their findings demonstrate the potential of this approach to enhance diagnostic reliability and support precision neuro-oncology.

Hydrogels derived from biopolymers have numerous applications in bioengineering, drug delivery, wound healing, and wearable devices. Yet, their strong swelling and uncontrollable degradation stimulate the development of hydrogels that overcome these limitations. Here, we report nanocolloidal hydrogels formed from nanoparticles of methacryloyl-modified biopolymers that exhibit resistance to swelling and enzymatic degradation both in vitro and in vivo, along with exhibiting a broad-range of mechanical and lubrication properties, wear resistance and biocompatibility. The nonswelling behavior of nanocolloidal hydrogels takes origin in the resistance to swelling of their hydrophobic regions which are resulted from the nanophase of hydrophobic methacryloyl groups in the interior of the constituent nanoparticles. The developed approach to the preparation of nanocolloidal hydrogel with greatly enhanced properties will have applications in long-term drug delivery and cell culture, soft tissue augmentation, and implantable bioelectronics.

A research team led by Professor Liu Maochang from Xi'an Jiaotong University has successfully developed an immobilized photothermal-photocatalytic integrated system. This innovative system combines a photothermal substrate with high-performance photocatalysts, enabling a synergistic process of liquid water evaporation and steam-phase water splitting for hydrogen production under light illumination without requiring additional energy input.

Polyploid crops often display enhanced vigor, larger organs, and unique reproductive behaviors, making polyploidization a powerful breeding tool. 

Understanding chromosome organization is crucial for plant genetics, but many tropical fruit crops lack reliable tools for chromosomal identification.