FSP1 (fibroblastspecific protein 1) was originally considered a marker of fibroblasts, but recent studies have confirmed that it is primarily expressed by a proinflammatory macrophage subset in liver injury and participates in the regulation of inflammation and fibrosis. This study systematically explores the interplay among these three elements.

When intense femtosecond laser pulses irradiate nanoparticles, the rapid energy deposition triggers a cascade of electronic and ionic responses within an extremely short time window, giving rise to transient nanoplasma shock waves-one of the most extreme states of matter reproducible in laboratory environments. These nanoscale shock waves offer a unique platform for studying mesoscale physical processes on ultrafast timescales, and hold promise for applications ranging from nanofabrication and compact laser-driven ion accelerators to targeted cancer therapies. However, achieving fine control over the spatial characteristics and propagation of nanoplasma shock fronts has remained a long-standing challenge.

In 94,344 UK Biobank participants, accelerometry objectively classified 24-hour rest-activity timing phenotypes. Over a median 6.8 years, the night-active phenotype was associated with higher incident MDD and anxiety risk, while an early-morning-active phenotype was associated with lower MDD risk.

The findings offer association evidence and exploratory MRI clues, but they do not establish that changing activity timing prevents mental disorders. Randomized trials are needed.

Prof. Yingxiang Liu's team at the State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, developed a unique tripodal piezoelectric robot driven by a high-stiffness ring-shaped elastic body. By combining axisymmetric vibration modes with an asymmetric foot arrangement, the proposed robot achieves both planar agile motions and high load capacity.