Researchers successfully built a time-calibrated lineage tree showing how a single cell turned into 1.28 million—about 10% of the cells in a two-week-old mouse embryo. This is by far the largest lineage tree ever built for a mammal.

A new gene signature and patient-derived models reveal the malignant neuroblastoma cells that have long been missed.

National Comprehensive Cancer Network participates in annual conferences for the International Gynecologic Cancer Society and Philippine Society of Medical Oncology in efforts to standardize cancer treatment recommendations.

An ultrasound-responsive micronanorobot combines a collagenase-secreting bacterium, bismuth ferrite nanoparticles, the drug DM4 and a targeting ligand to treat nonmuscle-invasive bladder cancer. After intravesical delivery, it degrades tumor matrix, enhances drug penetration, and ultrasound triggers reactive oxygen species, achieving 90.8% cell death in vitro and 82.4% tumor inhibition in mice. The system also promotes antitumor immunity, increasing CD8+ T-cell infiltration and shifting macrophages toward the M1 phenotype.