AI-powered atlas uncovered tertiary lymphoid structures as prognostic biomarkers

Research reveals drivers of treatment resistance in KRAS-mutant colorectal cancer and insights on which patients may benefit most from immunotherapy for various cancers

Scientists uncover the molecular pathways involved in blood vessel plaques

Immunotherapy could help treat potentially fatal fungal pneumonias  

Direct-to-consumer pharmacies may lower costs for generic prescriptions

About The Study: In this cross-sectional study, early age–onset colorectal cancer (EOCRC) was associated with improved overall survival compared with average age–onset colorectal cancer; however, treatment delays were independently associated with worse survival among patients with EOCRC. Language barriers could be a potentially modifiable risk factor associated with delayed treatment and may provide an opportunity to improve timely care and outcomes in EOCRC. 

Researchers at the Francis Crick Institute and University College London (UCL), funded by Cancer Research UK and the European Research Council (ERC), have identified a 14-protein signature in the blood that can predict lung cancer risk more than five years before diagnosis.

How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types? This question, debated for decades in cancer biology, is now gaining new insight thanks to the work of the Laboratory of Experimental Pathology (ULiège), in collaboration with researchers from Université Paris Cité and Sorbonne University.

Amplified Sciences, a clinical-stage diagnostics company pioneering next-generation multi-omic assays, today announced a new investment from the American Gastroenterological Association’s (AGA) GI Opportunity Fund as part of its recent Seed+ financing round. 

What happens if cancer cells lose both their mitochondrial energy supply and their glycolytic backup system? This question is central to a new study published in Research by researchers from Northwestern Polytechnical University and collaborating institutions. The work addresses a key limitation of cuproptosis-based cancer therapy: copper-dependent mitochondrial stress can kill cancer cells, but many tumors are metabolically flexible and rely heavily on aerobic glycolysis to survive mitochondrial damage. The study proposes a way to block both routes at once.