Adding the oncolytic virus immunotherapy pelareorep to paclitaxel chemotherapy warrants further investigation in patients with HR+ HER2- metastatic breast cancer whose disease has progressed after standard first-line treatment, according to PrECOG, LLC, the cancer research group that investigated the combination in the BRACELET-1 (PrECOG 0113) randomized phase 2 trial. 

Organ transplant recipients with advanced cancer, an often overlooked group in cancer care, may benefit from immunotherapy drugs, according to a new study.

The major international study, published in the prestigious JAMA Oncology journal, has revealed promising signs that cancer-fighting immunotherapy drugs, long considered too risky for organ transplant patients, may offer real benefits when carefully managed.

In this April 2025 issue of Annals of Thoracic Surgery (JCR Q1, IF: 3.6), a retrospective study, led by Professors Jianxing He and Shuben Li from the First Affiliated Hospital of Guangzhou Medical University, illustrated the safety, feasibility, and efficacy of extended sleeve lobectomy (ESL) after neoadjuvant immunochemotherapy in patients with centrally located non-small cell lung cancer (NSCLC).

The article entitled "Extended Sleeve Lobectomy After Neoadjuvant Immunochemotherapy for Centrally Located Non-small Cell Lung Cancer". It is the first study to evaluate the impact of neoadjuvant immunochemotherapy on ESL. The results demonstrated that ESL after neoadjuvant immunochemotherapy is a viable and safe option for selected patients with centrally located NSCLC to avoid pneumonectomy(PN), especially when standard sleeve lobectomy (SSL) is insufficient for R0 resection.

Researchers from Michigan State University and their partners have found new biological clues that could help doctors detect prostate cancer and heart disease earlier. This is the first time scientists have used a mix of tiny medical tools, or nanomedicine, artificial intelligence and a method called causal analysis to connect these clues directly to disease.This new diagnostic method has the potential to help millions of Americans.