Abnormal prenatal blood test results could indicate hidden maternal cancers
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Apr-2025 09:08 ET (30-Apr-2025 13:08 GMT/UTC)
Researchers at the National Institutes of Health (NIH) found previously undetected cancers in 48.6% of pregnant people who had abnormal results for prenatal cell-free DNA (cfDNA) testing used to screen for chromosomal disorders in the fetus. Cancers included colorectal, breast, lung and pancreatic cancers, as well as lymphoma, cholangiocarcinoma and renal carcinoma. The screening test analyzes placental DNA fragments circulating in the maternal bloodstream to identify an extra chromosome or to determine the baby’s sex. The study appears in the New England Journal of Medicine.
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