EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 15-Jul-2025 17:11 ET (15-Jul-2025 21:11 GMT/UTC)

New avenues in breast cancer treatment: The role of ubiquitin-specific proteases in programmed cell death

Compuscript Ltd
Peer-Reviewed Publication

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC remains a significant global health challenge. Despite advances in therapy, resistance to treatment and metastasis continue to pose major obstacles. This article presents a comprehensive analysis of how ubiquitination and deubiquitination processes, governed by USPs, influence various cell death pathways crucial to cancer progression and treatment response.

Journal: Genes & Diseases
Funder: University of South China Innovation Foundation For Postgraduate, Postgraduate Scientific Research Innovation Project of Hunan Province, National Natural Science Foundation of China, Clinical Medical Research “4310” Program of the University of South China

Traditional Chinese medicine unlocks new potential in treating diseases through ferroptosis regulation

Compuscript Ltd
Peer-Reviewed Publication

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis, offering novel therapeutic approaches for various conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and organ injuries. The powerful bioactive compounds in TCM have demonstrated the ability to regulate iron metabolism, lipid peroxidation, and redox balance, positioning them as key players in advancing modern medicine.

Journal: Genes & Diseases
Funder: National Natural Science Foundation of China, National Natural Science Foundation of China

Unveiling the role of tumor-infiltrating immune cells in endometrial carcinoma

Compuscript Ltd
Peer-Reviewed Publication

A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which tumor-infiltrating immune cells regulate endometrial carcinoma (EC). As one of the most prevalent gynecological cancers, EC continues to challenge researchers and clinicians due to its dynamic interaction with the immune microenvironment. This comprehensive review presents crucial insights into how immune cells influence tumor progression and how immune evasion strategies enable cancer cells to thrive.

Journal: Genes & Diseases

Prostate cancer is not a death knell, study shows

University of Washington School of Medicine/UW Medicine
Peer-Reviewed Publication

“Being diagnosed with prostate cancer is not a death knell,” said Montgomery, senior author of a literature and trial review that appeared in JAMA today. Montgomery is the clinical director of Genitourinary Oncology at Fred Hutch Cancer Center and University of Washington Medical Center, and a professor of medicine and urology at the UW School of Medicine.

Journal: JAMA

Four Penn cancer researchers elected as Fellows of the AACR Academy

University of Pennsylvania School of Medicine
Grant and Award Announcement

Distinguished cancer researchers Garrett M. Brodeur, MD, Susan Domchek, MD, Stephan Grupp, MD, PhD, and Robert Vonderheide, MD, DPhil, from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center have been elected to the 2025 class of Fellows of the American Association for Cancer Research (AACR) Academy.

Is red wine a healthier choice than white wine? Uncorking the cancer risks

Brown University
Peer-Reviewed Publication

Researchers from the Brown University School of Public Health have conducted a study that scours “the vast and often contradictory literature on the carcinogenicity of red and white wine” to assess whether this assumption holds up, and to compare the cancer risks associated with wine type.

Journal: Nutrients

New CAR-T cell therapy shows promise for hard-to-treat cancers

University of Colorado Anschutz Medical Campus
Peer-Reviewed Publication

Researchers at the University of Colorado Anschutz Medical Campus have successfully developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against cancer cells that are harder for prior CAR-T therapies to detect and fight.

Journal: Cancer Cell

FLIpping the Switch: Boosting stem cell numbers for therapies

Weill Cornell Medicine
Peer-Reviewed Publication

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to more effective bone marrow transplants and gene therapies.

Journal: Nature Immunology

Breakthrough combination therapy tackles drug resistance in lung cancer with common KRAS mutation

Virginia Commonwealth University
Peer-Reviewed Publication

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib—an FDA-approved drug in the market—and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer. The study, featured on the cover of the Journal of Thoracic Oncology, reveals a potential game-changer for patients battling tumors with the KRAS G12C mutation—a driver in about 14% of non-small cell lung cancers.

Journal: Journal of Thoracic Oncology
Funder: NIH/National Cancer Institute

Chronic stress and obesity work together to accelerate pancreatic cancer development and growth, study finds

University of California - Los Angeles Health Sciences
Peer-Reviewed Publication

A new study led by UCLA investigators suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer, shedding light on how lifestyle factors contribute to one of the deadliest malignancies.

Journal: Molecular Cancer Research
Funder: NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Diseases, Hirshberg Foundation for Pancreatic Cancer Research