Moffitt researchers analyze VA data to study prostate cancer disparities
Peer-Reviewed Publication
Prostate cancer is one of the most common cancers in American men, second only to skin cancer. One in eight men will develop the disease in his lifetime. While nearly 250,000 men will be diagnosed with prostate cancer each year, research has shown that the disease is often more aggressive and more deadly for African American men.
A new data portal called Cancer-Immu established by a team of Vanderbilt University Medical Center biostatisticians can help cancer clinicians and researchers predict which patients will respond to immune checkpoint inhibitors. With data from 3,652 samples for 16 cancer types, Cancer-Immu is the largest immune checkpoint blockade-related data portal for exploring immunogenomic connections.
What The Study Did: This analysis including 7.8 million patients found significant disparities in the incidence of localized and metastatic prostate cancer between African American and white veterans treated in the Veterans Affairs health care system.
Rates of cervical cancer screening have dropped in the U.S., with screening rates lowest among Asian and Hispanic women, as well as women who live in rural areas, don’t have insurance, or identify as LGBQ+, according to researchers with The University of Texas Health Science Center at Houston (UTHealth Houston).
After birth, the human mouth quickly becomes a hotbed of microbial variation. Streptococcus species largely dominate the oral cavity for the first 6 weeks of life, but the bacterial population diversifies with age and experience. Researchers study this early development, in part, to understand connections between the oral microbiota and associated diseases. An infant’s mother is likely a major source—if not the most important one—of the early oral microbiota. This week in mBio, dental researchers in Japan report a new analysis of how new mothers share microbes with newborns.
As reported in Advanced Photonics, researchers from Nanjing University recently developed a multifunctional, biocompatible, portable, and reusable microfiber probe based on a zinc oxide (ZnO) nanograting-integrated microfiber. It serves as a refractive index (RI) sensor for live, label-free sensing of intracellular RI distribution and real-time monitoring of cellular molecules.
Prostate cancer is the leading cause of cancer in men worldwide, and radiotherapy is one of the common forms of treatment. In a first-of-its kind meta-analysis, published today in The Lancet Oncology, researchers from University Hospitals (UH) and Case Western Reserve University show that there is consistent improvement in overall survival in men with intermediate- and high-risk prostate cancer with the addition of hormone therapy to radiotherapy treatments.
MD Anderson and Eisbach Bio have announced a strategic collaboration to jointly discover and develop new drugs that target synthetic lethal vulnerabilities in cancer.
Some of prostate cancers include a small number of aggressive cells hiding among the indolent ones like wolves in a herd of sheep. Researchers at Duke Health have identified a molecular signature that can spot these lurking threats.
Liver cirrhosis is a deadly disease that is still poorly understood, in large part due to the lack of animal models that allow it to be studied. The CNIO group led by Nabil Djouder has created the first genetically modified mouse that develops liver cirrhosis comparable to human cirrhosis and has thus managed to identify the molecular mechanisms underlying this disease. “Determining the molecular mechanisms causing cirrhosis will help us to understand how it progresses to liver cancer,” Djouder says.