Fat hack protects against cell death
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 13:15 ET (22-Jun-2026 17:15 GMT/UTC)
In response to stress or damage, cells undergo senescence and stop dividing. However, if senescent cells accumulate in tissues over the long term, chronic inflammation occurs and the risk of cancer increases. Researchers at the German Cancer Research Center (DKFZ) have now discovered a previously unknown mechanism by which senescent cells protect themselves from oxidative stress and a specific form of cell death known as ferroptosis. In the long term, these findings could provide new avenues for cancer therapies and the treatment of age-related diseases.
Drug delivery and diagnostic imaging often lack specificity, but a new “TRACE” method lets specially‑caged compounds stay inert until a target cell’s enzymes quickly remove the cage, potentially allowing for more precise drug delivery and sharper diagnostic imaging.
A new study in Science Bulletin presents DVSTP, a deep learning system that integrates pathology images with spatial transcriptomics and proteomics to map intra-tumor heterogeneity. DVSTP predicts molecular profiles from routine pathology slides, making spatial multi-omics more accessible. Whole–tumor 3D reconstruction reveals that SRSF6 drives immune exclusion and is associated with poor clinical outcomes.