- Researchers at CiQUS (University of Santiago de Compostela) have developed a strategy to activate an initially inactive molecule through chemical stimuli, enabling it to recognize and bind to a specific DNA structure known as a three-way junction (3WJ).

· These regions, implicated in tumor-related processes, are emerging as promising new targets for precision cancer therapies.

· The study has been featured on the cover of the prestigious journal Journal of the American Chemical Society (JACS).

A first-of-its-kind study, led by LaShae Rolle, a 27 y/o breast cancer researcher, survivor and elite powerlifter, challenges the long-held belief that cancer patients should stick to low- or moderate exercise and suggests that with individualized and symptom-informed exercise planning, even powerlifting can be safe and beneficial.

Specific way genetic material is organized in cells determines its ability to adapt to resist treatment. Scientists modulated this organization with an FDA-approved drug on the market. Strategy prevented cancer cells from adapting, making chemotherapy more effective in lab cultures and animal models of human cancer.

A group of University of Ottawa researchers have already shown how scientists can harness gene therapies to deliver nano-sized treatments for cancer, cardiovascular and other diseases. Unfortunately, the delivery agents in the process do not possess any therapeutic potential and ultimately degrade after acting as the messenger. So, the researchers asked: can we not develop nanoparticle platforms to be more than just mules? 

A molecular pathway used by pancreatic cancer cells to adapt to stress and inflammation could lead to earlier detection and treatment of the deadly disease.