Molecular profiling of over 1,000 nasopharyngeal cancer (NPC) patients’ tumours reveals distinct differences in tumour microenvironment of locoregionally advanced NPC, supporting the use of personalised treatment

Current treatment does not account for these biological differences, resulting in suboptimal outcomes

The study is the result of a 7-year-effort by the National Cancer Centre Singapore (NCCS), and validates ongoing clinical trials aimed at improving standards of care

For the first time, researchers have found that lung cancer patients who have a combination of high levels of depression and inflammation at diagnosis are later found with continuing depressive symptoms in the next several months, even as they receive new, promising therapies. The study found that having both maladies at diagnosis predicted higher, continuing levels of depression during the next eight months. Those who had only high levels of depression or only high levels of inflammation, or neither of them, showed no changes in depression over time.

In this April 2025 issue of Translational Lung Cancer Research, a pioneering study, led by Professor Shuben Li from the First Affiliated Hospital of Guangzhou Medical University, revisits a classic but unresolved question in airway surgery: Should tracheobronchial anastomoses be routinely wrapped following resection and reconstruction?

The article, titled "Tracheobronchial resection and reconstruction: to wrap or not to wrap the anastomosis?"，presents a single-center experience to explore the relationship between wrapping the anastomosis after airway reconstruction and short-term surgical outcomes, and to investigate whether wrapping the anastomosis can reduce the incidence of postoperative adverse events.