A new blood test may detect leukemia risk and replace bone marrow sampling
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-Jul-2025 17:10 ET (1-Jul-2025 21:10 GMT/UTC)
Van Andel Institute scientists and collaborators have discovered a potential treatment target that may re-energize dysfunctional or “exhausted” immune cells in their fight against cancer.
The target is an immune checkpoint called PTGIR, which regulates the number and cancer-fighting powers of T cells, the soldiers of the immune system. Too much PTGIR puts a brake on T cells and reduces their ability to release cancer-killing molecules.
The findings, published in the journal Nature Immunology, could help improve cancer immunotherapies by paving the way for new immune checkpoint inhibitors or engineered T cell therapies that block PTGIR signaling and re-invigorate T cells.
A cup and a half of leafy green vegetables could go a long way to addressing atherosclerotic vascular diseases (ASVD’s), new research from Edith Cowan University (ECU), the University of Western Australia and the Danish Cancer Institute has found.
In May 2025, the Journal for ImmunoTherapy of Cancer published a pioneering study entitled “NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC”, led by Professor Jianxing He’s team from the First Affiliated Hospital of Guangzhou Medical University / National Center for Respiratory Medicine.
The study introduces NeoPred, a multimodal artificial intelligence model that combines dual-phase CT scans (pre-treatment and pre-surgery) and clinical features to predict major pathological response (MPR) before surgery in patients undergoing neoadjuvant chemo-immunotherapy for non-small cell lung cancer (NSCLC).
Corresponding Authors: Prof. Jianxing He, Dr. Hengrui Liang Co-First Authors: Dr. Jianqi Zheng, Mr. Zeping Yan, Mr. Runchen Wang Collaborating Institutions: Shanghai Chest Hospital, Liaoning Cancer Hospital, First Affiliated Hospital of Xi’an Jiaotong University
Blood cancer patients who may have previously struggled to find a donor for transplantation now have more options. A new study shows that patients achieve good outcomes with a partial match drawn from the national public registry of donors when they are treated with the immune-suppressing drug cyclophosphamide.
It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances. Surprisingly, they found that imbalanced proteome changes impair mitochondrial function. This, in turn, could be relevant for the drug treatment of cancer. The results are published in the journal Nature Communications.
A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer—drive tumor initiation formation and therapeutic resistance.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Promising treatment results for blood cancers, colorectal cancer and brain metastases. Novel insights into early pancreatic cancer cell progression. A new therapeutic target for patients with high blood pressure