Artificial intelligence (AI) is transforming healthcare across multiple fields, and prostate cancer (PCa)  is no exception. A recent review conducted by researchers discusses the role of AI in clinical practice against PCa. According to this study, AI models enable early detection of PCa with high accuracy while minimizing errors. AI models used in molecular subtyping and precision medicine also offer personalized treatments—improving the overall quality of life of patients.

This study addresses the critical gap in epidemiological data on antenatal depression in China, a condition that profoundly impacts maternal and infant health. Conducted as a cross-sectional survey from December 2019 to March 2023, the research enrolled 100,200 pregnant women across 27 hospitals in 11 provinces, municipalities, and autonomous areas. Late-pregnancy depressive symptoms were evaluated using the Edinburgh Postnatal Depression Scale (EPDS). This survey reveals that the overall prevalence of possible depression (EPDS >9) was 25.8%, and probable depression (EPDS >12) was 11.4%, with significant regional variation (highest in North China, lowest in East China). Young maternal age, low education levels, low family income, unemployment, living alone, unmarried/divorced status, unintended pregnancy, multiple pregnancy, insufficient social support, tobacco/alcohol use, and poor sleep quality were identified as risk factors for antenatal depression. Notably, family support, particularly from partners, emerges as a pivotal intervention target for reducing antenatal depression risk.

Professor Chuang Yu from Huazhong University of Science and Technology significantly enhanced the air stability of chlorine-rich Li₅.₅PS₄.₅Cl₁.₅ electrolyte and improved the electrochemical performance of all-solid-state lithium metal batteries through a phosphate group doping strategy.

Boron-based compounds are known as a class of anion acceptors. Now, writing in the journal Science China Chemistry, a team of researchers from Nankai University use this chemistry in electrolyte design. According to the study, boron-based additives have been found to reduce charge transfer resistance, improve the Li-ion diffusion kinetics, and stabilize high-voltage cathode of batteries. The findings demonstrated versatileness of B-ads that effectively mitigated the critical challenges of energy-dense battery systems.

Recently, a research team led by Professor Caifu Jiang from China Agricultural University published a study titled "The ZmMPK3-ZmGRF1 module promotes maize growth by enhancing cell proliferation under salt stress" in Science Bulletin. This study shows that the ZmMPK3-ZmGRF1 module facilitates maize growth under salt stress through enhanced cell proliferation, providing new insights into how MPK signaling pathways and GRF growth regulators govern plant responses to saline environments. Furthermore, these findings offer valuable genetic resources for developing salt-tolerant maize varieties.

In medicine permanent magnets demonstrate unique advantages in terms of field strength, tunability of field and gradient distributions, and practical implementation. The findings highlight the critical role of spatial magnetic field characteristics in optimizing the interaction of magnetic fields with biological tissues and cells, thereby improving the efficacy of magnetic medical technologies. The insights derived from this study emphasize the transformative potential of permanent magnet systems in shaping the future of both magnetic surgery and therapeutic applications in medicine.

The study investigates the interaction between the human epidermal growth receptor 2 (HER2) and amygdalin, a compound found in peaches, almonds, and apples. To assess the potential of amygdalin, the interaction between HER2 and amygdalin was explored using molecular docking and molecular dynamics simulations. Binding energies were evaluated for both the crystal and equilibrated HER2 structures. The effects of water on binding were also assessed. Molecular dynamics simulations analyzed structural changes in HER2, including interdomain distances, hydrogen bond fluctuations, dihedral angle shifts, and residue-residue distances at the dimerization arm. The free energy landscape was constructed to evaluate stability. Binding energies of −33.472 ​kJ/mol and −36.651 ± 0.867 ​kJ/mol were observed for the crystal and equilibrated HER2 structures, respectively, with water further enhancing binding to −41.212,4 ​± ​1.272,7 and −53.513 ± 1.452,3 ​kJ/mol. Molecular dynamics simulations revealed significant conformational changes in HER2, including a reduction in interdomain distance, fluctuations in hydrogen bond lengths, and a shift in dihedral angles from 60° to −30°. The residue-residue distance at the dimerization arm decreased, indicating conformational changes upon binding. The free energy landscape showed a deeper and more defined minimum in the bound state, reflecting enhanced stability. These findings highlight amygdalin’s potential as a therapeutic agent targeting HER2.

Objective: Children with autism spectrum disorder (ASD) had lower vitamin D3 levels than neurotypical (NT)

children, as well as de cits in language, social, and ne motor abilities. Nanotechnology has appeared as a

suitable answer to absorption and bioavailability problems related to vitamin D3. This study aims to investigate

the in uence of vitamin D3-loaded nanoemulsion supplementation on adaptive behavior and language perfor-

mance in children with ASD compared to the in uence of the marketed product of vitamin D3.

Methods: Supplementation of ASD children with an oral vitamin D3-loaded nanoemulsion was performed in group

I while the marketed product of the oral vitamin D3 was used in group II for 6 months. Evaluation of their abilities

and measuring the plasma levels of 2 types of vitamin D3 were performed using ultra-performance liquid chro-

matography before and after supplementation.

Results: Supplementation in group I (n ¼ 40) has led to an elevation of levels of 25 (OH) and 1, 25 (OH)2 forms of

vitamin D3 (P < 0.000,1), to behavioral improvement in the form of a reduction in ASD severity, and to a rise in

the social IQ and total language age of ASD children (P¼ 0.000,2, 0.04, 0.000,9, respectively). On the other hand,

group II (n ¼ 40) did not show adaptive behavioral improvements.

Conclusions: The vitamin D3-loaded nanoemulsion provided better vitamin D3 bioavailability and a true in uence

on severity, adaptive behavior, ne motor abilities, and language performance, re ecting the desired bene ts of

the rise of vitamin D3 levels in the blood.

Low ionic conductivity is a major obstacle for polymer solid-state electrolytes. In response to this issue, a design concept of enhanced regional electric potential difference (EREPD) is proposed to modulate the interaction of nanofillers with other components in the composite polymer solid-state electrolytes (CPSEs). While ensuring the periodic structure of the graphdiyne (GDY) backbone, methoxy-substituted GDY (OGDY) is prepared by an asymmetric substitution strategy, which increases the electric potential differences within each repeating unit of GDY. The staggered distributed electron-rich regions and electron-deficient regions on the two-dimensional plane of OGDY increase the free Li⁺ concentration through Lewis acid–base pair interaction. The adjacent ERRs and EDRs form uniformly distributed EREPDs, creating a continuous potential gradient that synergistically facilitates the efficient migration of Li⁺. Impressively, the OGDY/poly(ethylene oxide) (PEO) exhibits a high ionic conductivity (1.1 × 10^-3 S cm^-1) and ion mobility number (0.71). In addition, the accelerated Li⁺ migration promotes the formation of uniform and dense SEI layers and inhibits the growth of lithium dendrites. As a proof of concept, Li||Li symmetric cell and Li||LiFePO₄ full cell and pouch cell assembled with OGDY/PEO exhibit good performance, highlighting the effectiveness of our EREPD design strategy for improving CPSEs performance.