Tonic signaling in CAR-T therapy: The lever long enough to move the planet
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Oct-2025 22:11 ET (19-Oct-2025 02:11 GMT/UTC)
Chimeric antigen receptor T cell therapy has reshaped expectations for treating hematological malignancies and is now reaching toward autoimmune disorders, fibrosis, and even aging. Engineered receptors couple an antibody-derived binding domain with T-cell signaling modules, granting exquisite specificity and long-lived memory. More than 1,700 trials are under way, with the United States and China leading in both clinical testing and the use of AI design platforms such as CAR-Toner. Six FDA-approved products target CD19 or BCMA, while China has granted marketing authorization to five additional constructs. Beyond oncology, CD19-directed cells have produced drug-free remission in systemic lupus erythematosus, myositis, sclerosis, and myasthenia gravis; FAP-directed or senolytic CAR-T cells are being explored for cardiac fibrosis and age-related decline, illustrating the widening therapeutic canvas.
Researchers isolated antibiotic-resistant Staphylococcus saprophyticus from the Southern Ocean. The bacteria showed resistance to multiple antibiotics, including Azithromycin and Cefixime, highlighting the far-reaching impact of human activity on microbial ecosystems.
Beihang University researchers unveil a new federated learning poisoning-attack mitigation strategy to cap accuracy losses under 1% on MNIST and under 4% on CIFAR-10, bolstering AI security and privacy in healthcare, autonomous vehicles, and finance.
Researchers at the National University of Defense Technology and Shanghai Jiao Tong University introduce a symmetry-aware neural network architecture that slashes multi-agent reinforcement learning training time by up to 70%, doubles predator–prey task performance, and boosts sample-efficient coordination for autonomous traffic control, cooperative robotics, and power-grid management.
Researchers from Hefei University of Technology and Tsinghua University have developed a new cognitive diagnosis approach that overcomes student-concept sparsity to boost accuracy by up to 6%, delivering more accurate, real-time personalized learning analytics and equitable feedback.
Researchers at Nanjing University and China Mobile unveil a novel privacy-preserving traffic-engineering algorithm that cuts multi-domain routing time by 24.35% while maintaining 90% link utilization through differential privacy and graph neural network–driven bandwidth prediction.
A new multilingual AI survey by Beijing Foreign Studies University researchers uncovers uneven training data, cross-lingual alignment challenges, and embedded bias in 50+ large language models—offering a roadmap for balanced corpora, universal representation, and robust bias mitigation to boost low-resource language support.