Earth's heart is frozen yet flowing
Peer-Reviewed Publication
Updates every hour. Last Updated: 17-Jan-2026 02:11 ET (17-Jan-2026 07:11 GMT/UTC)
A new study in National Science Review have experimentally uncovered a suprising new state of matter within Earth's inner core–a superionic iron light-element alloy. In this state, light elements like carbon move freely, almost like a liquid, within solid hcp-iron lattice. This discovery helps explain puzzling seismic signals such as strong shear softening and an ultrahigh Poisson's ratio in the solid inner core, reshaping our understanding of the planet’s hidden heart.
A research paper just published in Science China Life Sciences reports that the fungal virulence factor oxalic acid (OA) dampens plant immunity by exploiting pH-dependent inhibition of the chitin coreceptor CERK1 Asn70 deamidation, which positively regulates chitin-triggered plant immunity and is monitored by an endogenous immune surveillance, establishing a mechanistic link between pathogen-derived acidity, post-translational modification (PTM) of host immune receptors, and suppression of host immunity.
The aberrant overexpression of Lysine-specific demethylase 1 (LSD1/KDM1A) is a common feature across a wide spectrum of human cancers, and its elevated levels correlate with poor survival of cancer patients, making it an attractive target for pharmacological intervention. However, the clinical trials of LSD1 small-molecule inhibitors are facing few serious challenges, including toxicity at therapeutic doses. Here, the authors reported the discovery of LD-110 as a potent PROTAC degrader via the ubiquitin-proteasome system, leading to significantly growth suppression of cancer cells both in vitro and in vivo.
Gout, a curable arthritis, now aims for long-term remission over flare control. Professors Towiwat and Li's review in the journal Rheumatology & Autoimmunity synthesizes evidence to define remission, identifies key challenges, and outlines comprehensive management strategies. This work provides clinicians with clear, practical guidance for achieving sustained disease control.
A collaborative European research team led by physicists from Slovak Academy of Sciences has theorized a new approach to control spin currents in graphene by coupling it to a ferroelectric In2Se3 Monolayer. Using first-principles and tight-binding simulations, the researcher showed that the ferroelectric switching of In2Se3 can reverse the direction of the spin current in graphene acting as an electrical spin switch. This discovery offer novel pathway toward energy-efficient, nonvolatile, and magnet-free spintronic devices, marking a key step toward the fabrication of next-generation spin-based logic and memory systems.to control spin textures
A new critical review published in Materials Futures traces the rapid evolution of Refractory High-Entropy Alloys (RHEAs), a revolutionary class of materials engineered for extreme environments. The review, led by researchers from Shanghai Jiao Tong University, highlights a paradigm shift from traditional alloy design towards computational- and microstructurally-guided strategies. It details how advanced tools like machine learning, quantum mechanics simulations, and phase diagram calculations are accelerating the discovery of new compositions. A central focus is on innovative microstructural designs, including metastable engineering, heterogeneous structures, and atomic-scale chemical ordering, that are successfully overcoming the long-standing trade-off between strength and ductility. The authors conclude that the integration of multi-scale modeling, in-situ characterization, and closed-loop data analysis is poised to transition RHEAs from laboratory breakthroughs to critical components in aerospace, energy, and nuclear applications.
Recently, Associate Professor Xiaolong Feng from the College of Economics and Management at China Agricultural University, together with researchers from the Alliance for a Green Revolution in Africa (AGRA), has addressed these questions through a comparative analysis of agricultural subsidy policies in China and Africa. The related article has been published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2025624).
Recently, an in-depth study addressing this question was jointly conducted by Associate Professor Ting Meng from the College of Economics and Management at China Agricultural University, in collaboration with researchers from the Research Institute for Eco-civilization of the Chinese Academy of Social Sciences and the Alliance of Biodiversity International and International Center for Tropical Agriculture (Senegal). The study offers systematic solutions for developing countries, and the related article was published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2025646).
This study developed and evaluated a novel transferosomal gel formulation incorporating luliconazole to enhance topical antifungal therapy. Luliconazole, an imidazole antifungal drug, is widely prescribed for dermatophytic infections such as tinea pedis, tinea cruris, and tinea corporis. However, conventional topical formulations often suffer from poor skin penetration, low drug bioavailability, and the need for frequent application, which may reduce patient compliance.
In this work, transferosomes were prepared using thin film hydration with lecithin and Tween 80 at varying concentrations, followed by incorporation into a carbopol gel base. The transferosomes demonstrated high entrapment efficiency of 74.45% and 92.75% with particle sizes ranging between 60–200 nm, and scanning electron microscopy confirmed their spherical morphology. The in vitro release study revealed an inverse relationship between entrapment efficiency and release rate, indicating a controlled and sustained release behavior.
The formulated transferosomal gel was further characterized for pH, drug content, spreadability, and viscosity, all of which fell within acceptable ranges for topical application. Importantly, antifungal activity testing confirmed that the luliconazole transferosomal gel exerted a strong therapeutic effect against dermatophytes.
Overall, the study highlights the potential of transferosomal technology to overcome the limitations of conventional antifungal formulations. By improving drug penetration and sustaining drug release, the luliconazole transferosomal gel reduces the frequency of application required, which may enhance treatment adherence and patient outcomes. These findings underscore the promise of transferosome-based gels as a novel drug delivery strategy for managing dermatophytic skin infections effectively.