A study of non-functional pancreatic neuroendocrine tumors (NF-PanNETs) identified an AGR2^high endocrine subcluster enriched in high-grade tumors and showed that simple AGR2 immunohistochemistry serves as a clinically informative prognostic marker. Mechanistically, the transcription factor FOXM1 directly drives the proliferative transcriptional program of AGR2^high cells, while chemical inhibition of FOXM1 showed therapeutic benefit in tumor cells, patient-derived organoids, and xenograft models. Together, the findings provide a new approach for prognostic stratification and identify FOXM1 as a potential therapeutic vulnerability in NF-PanNETs.

Eco-nanozymology, as an emerging interdisciplinary field, integrates nanotechnology with principles of enzymology to offer innovative strategies for energy conversion and environmental remediation. In contrast with conventional enzymology, eco-nanozymology enhances catalytic efficiency through the precise regulation of interfacial microstructures, electronic distributions, active site configurations, multienzyme cascade catalysis, and functionalized carrier engineering. By harnessing and amplifying natural ecological processes, eco-nanozymology enables effective modulation of energy flow and material cycling within ecosystems. This review focuses on recent advances in the application of eco-nanozymology across energy-related domains, including nitrogen fixation, carbon fixation, methane oxidation, hydrogen production, and energy conversion devices. It further provides an in-depth analysis of the recent progress in the efficient degradation of environmental pollutants and resource-oriented valorization of low-value biomass, such as lignin, agricultural residues, livestock manure, and microplastics. These studies highlight the pivotal role of eco-nanozymology in enhancing the efficiency of environmental management, accelerating the development of green energy technologies, and advancing carbon neutrality goals. The continued development of eco-nanozymology is expected to open new horizons for the deepening and expansion of nanozyme applications, offering green, environmentally friendly, and sustainable technological pathways to address global energy and environmental challenges.

Artificial solid electrolyte interphase offers a promising route to improve the lifespan and safety of quasi-solid-state sodium-metal batteries (QSMBs), yet its limited ion conductivity and the low liquidity of the polymer electrolyte often result in unstable Na plating/stripping kinetics and poor interfacial durability. Herein, we propose a surface-induced “top” Na deposition mechanism facilitated by an ultra-sodiophilic ionic/electronic mixed conductor interphase exhibiting strong Na⁺ adsorption affinity, which ensures fast and dendrite-free Na anode operation. The embedded Na₃Sb alloy phase, featuring high electronic conductivity and strong Na⁺ adsorption energy, significantly accelerates interfacial ion diffusion and nucleation kinetics, forming a smooth and compact Na deposition layer that facilitates stable solid electrolyte interphase formation and preserves interfacial integrity. Consequently, Na||Na symmetric cells employing a 1, 3-dioxolane-based gel polymer electrolyte deliver an ultra-long-cycling lifespan of 1000 h at 0.5 mA cm⁻² with a low overpotential of 40 mV. Moreover, QSMBs incorporating the modified Na anode and Na₃V₂(PO₄)₃ cathode demonstrate outstanding cycling stability (74.1% capacity retention after 9000 cycles at 2C) and superior rate capability (91.7 mAh g⁻¹ at 5C). The work provides mechanistic insights and practical strategies for regulating Na deposition, paving the way toward high-performance QSMBs.

Aqueous zinc-ion batteries are promising candidates for large-scale energy storage, yet their development is severely hindered by the interfacial instability of zinc anodes. Distinct from strategies employing pre-formed polymers, this work proposes an innovative monomer-induced in situ interface engineering strategy. By leveraging the preferential adsorption of acrylamide monomers on the Zn surface, a locally high-concentration region is created, which subsequently enables the in situ construction of a stable hydrated network interphase (HNI) triggered synergistically by Zn²⁺ and SO₄²⁻ during electrochemical cycling. The HNI precisely regulates Zn deposition via a triple synergistic mechanism: Lewis acid–base coordination (C = O···Zn²⁺) provides fixed nucleation sites; dynamically anchored SO₄²⁻ within the interphase forms negatively charged microregions that homogenize Zn²⁺ flux via Coulombic repulsion; and a dense hydrogen-bonding network effectively confines free water and suppresses side reactions. Benefiting from this multifunctional interphase, the Zn//Zn symmetric cell achieves an ultra-long cycling life of 8650 h (over 360 days) at 1 mA cm⁻² with excellent reproducibility, the Zn//Ti cell delivers a high average Coulombic efficiency of 99.71% at 5 mA cm⁻². The Zn//I₂ full cell retains 89.15% of its capacity after 12,000 cycles. This work provides a novel paradigm for interfacial construction toward high-performance zinc metal anodes.

A research team from Shanghai Jiao Tong University has developed a physics-informed neural network for distributed acoustic sensing. The approach generates synthetic event data and removes background noise without relying on real-world event data. Demonstrated in public datasets and belt conveyor fault monitoring, the method achieves high accuracy and generalizes across different sites, offering a scalable solution for industrial monitoring and optical sensing applications.