The team proposed to estimate the amplified effect of popular nodes on each node's representation, and intervene the effect after each graph convolution.

In China, the real-world effectiveness and safety of Janus kinase 1 (JAK1) inhibitors for moderate-to-severe atopic dermatitis (AD) are of significant interest due to the approval of upadacitinib and abrocitinib in the country. Despite their demonstrated efficacy in clinical trials, there is a scarcity of real-world data, particularly pertaining to Asian demographics. Addressing this gap, a single-center, 24-week prospective study was undertaken at Xiangya Hospital to evaluate the practical application of abrocitinib and upadacitinib in a Chinese cohort of AD patients.

A new biomass densification pretreatment method using sulfuric acid and metal salts under mild conditions boosts bioethanol production efficiency. It offers cost-effective alternatives for industrial biofuel production and converts residual biomass into bio-adsorbents for dye wastewater treatment, marking an advance in sustainable biorefinery technology.

With an increasing focus on environmental sustainability, researchers are seeking ways to improve the biodegradability and mechanical properties of bioplastics, particularly polylactic acid (PLA). A recent study by June-Ho Choi and colleagues, published in the Journal of Bioresources and Bioproducts, presents a promising approach that enhances the compatibility and decomposition of PLA when combined with biomass through a process called torrefaction. This innovation offers practical improvements for sustainable material applications, positioning PLA as a viable, eco-friendly alternative in various industries.

This study introduces a novel lignin-based hydrogel with controlled release and enhanced mechanical strength, leveraging lignin's antioxidant and antimicrobial properties. The hydrogel shows promise in wound healing and drug delivery due to its pH-responsive release behavior, high cell viability, and reactive oxygen species scavenging capability.

Recent advancements in cyanobacteria engineering have demonstrated increased ethanol production through genetic modifications and environmental adaptations. This study outlines key strategies in carbon flow optimization and enzyme overexpression, enhancing ethanol yields. The findings underscore cyanobacteria's potential as a renewable biofuel source, marking significant progress in sustainable energy research.

Nitrogen and potassium are fundamental nutrients for plant growth, but imbalances frequently disrupt agricultural systems.

A pivotal study has uncovered a genetic defense mechanism in lily plants against Botrytis cinerea, the fungus behind gray mold disease. Central to this defense is LlHSFA4, a transcription factor that, when activated, initiates a robust response against the pathogen.

Researchers at UC San Diego have examined the critical role of goblet cells in gut immunity and health. GCs create a mucus barrier that protects against pathogens while supporting beneficial bacteria. They also deliver antigens to immune cells, promoting gut tolerance. Disruptions to goblet cell functions can contribute to gastrointestinal diseases like colorectal cancer and inflammatory bowel disease, making them a promising therapeutic target for maintaining gut health and combating various gut-related conditions.