A research team has developed an advanced framework that combines unmanned aerial vehicle (UAV) phenotyping with spatiotemporal deep learning and dynamic modeling to evaluate soybean density tolerance.

A research team has developed a ferromanganese oxide-modified biochar that achieved exceptional performance in eliminating copper–citrate (CuCA) complexes from contaminated water.

A research team has developed a novel framework to address the growing challenges of ecological security in cold regions, which are particularly vulnerable to the combined impacts of climate change and anthropogenic pressures.

A research team has uncovered significant insights into how crop-specific metabolites influence the spread of antibiotic resistance genes (ARGs) in soil-plant systems.

A research team reveals how iron mineral-Bacillus megaterium (B. megaterium) biofilms function as "biocapacitors," storing solar energy and releasing it in dark environments to degrade harmful contaminants.

This review identifies PI3K/AKT/mTOR pathway activation, hypoxia (mediated by HIF-1), and glucose metabolism (glycolysis, PPP, OXPHOS) as core drivers of SCLC radioresistance. Innovatively, it clarifies their crosstalk: PI3K/AKT/mTOR regulates glucose metabolism via HIF-1 and by inhibiting G6PD ubiquitination. Clinically, targeting these axes—with PI3K/mTOR inhibitors, HIF-1 antagonists, or glucose metabolism blockers—may enhance SCLC radiosensitivity, providing actionable strategies to overcome 放疗 resistance in this aggressive cancer.

This review in Cancer Pathogenesis and Therapy emphasizes T cells’ central role in cancer immunotherapy, covering CD4+/CD8+ T cell interactions, key strategies (CAR-T, anti-PD-1/CTLA-4), and challenges (T cell exhaustion, metabolic impairments). It highlights memory T cells’ potential. Innovatively, it dissects T cell functional mechanisms and limitations. Clinically, it provides insights to optimize T cell-based therapies (e.g., CAR-T, checkpoint blockade) and explore memory T cell applications, guiding more effective immunotherapeutic strategies.