Researchers from Kunming Institute of Botany, Chinese Academy of Sciences synthesize current understanding of how climate change over the past decades and overexploitation of resources by human activities interact to threaten plant diversity in QTP.

Cancer cachexia is commonly present in various cancers, including live, pancreatic, gastroesophageal, and bile duct cancers, and is associated with chemotherapy toxicity. M-MDSC induces mTEC apoptosis and impairs T cell negative selection, which leads to autoimmune T-cell infiltration of normal organs and serves as a prerequisite for the occurrence of irAEs. In addition, irAEs patients have higher levels of circulating M-MDSCs. M-MDSCs associated with cancer cachexia can serve as potential predictive biomarkers for irAE in advanced cancer patients.

This review highlights how natural polysaccharide-based microneedles (PMNs) are emerging as a transformative platform for cancer immunotherapy. We report their unique dual role in drug delivery and immune regulation, the innovative use of 3D printing for precision fabrication, and their smart responsiveness to the tumor environment. By integrating biocompatibility, enhanced drug loading, and controlled release, polysaccharide-based microneedles (PMNs) offer a promising strategy to overcome challenges in traditional cancer immunotherapies, potentially supporting the development of more effective and personalized treatments.

 Undiagnosed trauma is a silent driver of chronic illness, often missed by healthcare systems. This study introduces Emotional Memory Images (EMIs) as subconscious imprints formed in overwhelming moments that continue to affect mental and physical health, offering a rapid, non-invasive method to clear them.

Beijing’s metro could quietly carry freight during off-peak hours without new tunnels, a joint timetable–rolling-stock model shows. Flexible train compositions and selective skip-stop patterns cut operating costs by up to 25% while keeping passenger delays minimal.

Discover how human adipose tissue can be transformed into functional organoids representing all three germ layers—mesoderm, endoderm, and ectoderm—using a novel, streamlined method. This new study published in Engineering highlights the potential of adipose tissue for regenerative medicine, offering a scalable and clinically relevant alternative to traditional organoid generation techniques.

This article explores the potential of large language models (LLMs) in reliability systems engineering, highlighting their applications in improving industrial efficiency and flexibility. It also examines the challenges, including data deficiencies and complexity, and suggests future directions for integrating LLMs into complex engineering processes.

A new study in Engineering introduces a novel MRI technique enabling real-time, artifact-free navigation of magnetic robots. Using a multi-frequency dual-echo sequence, researchers achieved a 30-millisecond repetition time, allowing precise control and high-resolution imaging. Demonstrations in maze, phantom vessel, and in vivo trials highlight its potential for minimally invasive therapies.