The development of synthetic embryo models using early stem cells has emerged as a powerful platform for studying mammalian development in vitro. However, the generation of high-quality post-implantation embryo models in mice has typically relied on embryonic stem cells (ESCs) engineered to transiently express master regulators of extraembryonic lineages. This strategy diverges from the natural in vivo process of extraembryonic lineage specification.

The endocrine system plays a crucial role in regulating physiological processes and maintaining homeostasis. While previous studies have examined aging in individual endocrine organs, a comprehensive investigation across multiple endocrine tissues at single-cell resolution has been lacking. This study established the first single-cell aging atlas of the endocrine system, revealing conserved and organ-specific aging mechanisms while identifying novel regulatory pathways.

γ-ray astronomy has matured significantly over the course of the last decade and a half, leading to the exploration of the high-energy universe with unprecedented sensitivity. The observation of the low-energy γ-ray (0.1 to 30 MeV) sky has been significantly limited since the Imaging Compton Telescope (COMPTEL) instrument aboard the Compton Gamma Ray Observatory (CGRO) satellite was decommissioned in 2000. The exploration of γ-ray photons within this energy band, often referred to as the MeV gap, is crucial to address numerous unresolved mysteries in high-energy and multi-messenger astrophysics. Although several large MeV γ-ray missions have been proposed (e.g., e-ASTROGAM, AMEGO, and COSI), most of these are in the planning phase, with launches not expected until the next decade, at the earliest. Recently, there has been a surge in proposed CubeSat missions as cost-effective and rapidly implementable pathfinder alternatives. An MeV CubeSat dedicated to γ-ray astronomy could serve as a valuable demonstrator for large-scale future MeV payloads.

Researchers led by Prof. XU Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, revealed the important roles of POSH phase separation and its co-condensates with SHANK2/3 in the synaptic targeting of SHANK2/3 and synaptogenesis.

Hydrogen peroxide (H₂O₂) plays essential roles in industrial processing, food production, and biological systems, but excessive residues pose health and safety concerns.

Although biodegradable plastics are promoted as eco-friendly alternatives, their microplastic residues may linger in soil for extended periods.

Leaf vasculature plays a pivotal role in nutrient transport and leaf morphology.