This study demonstrates that preoperative VEGFR-TKI plus ICI therapy, combined with 3D reconstruction-guided robotic cytoreductive nephron-sparing surgery, is safe and feasible in locally advanced clear cell renal cell carcinoma. This integrated approach increased the feasibility of nephron-sparing surgery, reduced perioperative morbidity, and improved renal functional preservation. It also provided significant progression-free and overall survival advantages, accompanied by marked tumor immune microenvironment remodeling with enhanced TLS formation and immune-cell infiltration.

A team led by Guoyin Yin at Wuhan University and the Shanghai Artificial Intelligence Laboratory recently proposed a modular machine learning framework using LoRA fine-tuning. This framework can not only accurately predict single organic reactions but also achieve the prediction of "one model handling multiple types of reactions." Even using only natural language to describe chemical reactions, the prediction accuracy is comparable to machine learning models based on expert experience. The article was published as an open access Research Article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.

Corn cob biochar made from farm waste can remove up to two thirds of ammonia and almost all micro and nanoplastics from water, while avoiding the release of toxic byproducts and remaining reusable over multiple treatment cycles.

A new study shows how digital building models can be used to pinpoint where carbon emissions occur across a building’s entire life cycle, offering designers and policymakers a powerful tool to reduce the climate footprint of the construction industry.

In a surprising twist amid rising climate concerns, new research shows that scorching soil temperatures during extreme heatwaves do not necessarily boost the uptake of toxic elements like arsenic in rice crops. This finding, from a real world experiment during China's record breaking 2022 heatwaves, challenges fears that global warming will poison staple foods.

A recent study led by Prof. ZHANG Xiaoming's team at the Institute of Zoology of the Chinese Academy of Sciences (CAS), in collaboration with Prof. Ian T. Baldwin's group at the CAS Center for Excellence in Molecular Plant Sciences, has uncovered a novel ecological strategy. Rather than passively "hitchhiking" within insect vectors, rice viruses actively manipulate plant defense pathways to protect their insect carriers. This discovery reshapes our understanding of plant–virus–insect–parasitoid interactions and provides new insights for sustainable pest and pathogen management.