Valencia, Spain will host Targeting Extracellular Vesicles 2025 on October 15–16, uniting global experts to explore how extracellular vesicles (EVs) are revolutionizing diagnostics and therapeutics. With the theme “Bridging Two Frontiers: Mitochondria & Microbiota”, the event will reveal how EVs connect cellular energy metabolism and microbiome science, two key systems influencing human health. 
Sessions will feature cutting-edge research, clinical applications, and technology showcases aimed at breakthroughs in cancer, neurodegeneration, metabolic disorders, and immune health. Abstracts are invited until September 10, 2025.

Neuroblastoma, a deadly childhood cancer, has long defied precise predictions due to its biological complexity.

A team of international researchers has published a comprehensive review in Advanced Science detailing how combining protein three-dimensional spatial structures with artificial intelligence is reshaping the way scientists predict and design drug combinations. By integrating high-resolution protein modeling with advanced AI algorithms, the approach offers unprecedented accuracy in identifying synergistic and antagonistic effects, paving the way for safer and more effective treatments for cancer, infectious diseases, and metabolic disorders.

Tokyo, Japan – Researchers from Tokyo Metropolitan University have discovered a new pathway by which cells counteract the action of alovudine, an important antiviral and anticancer drug. The protein flap endonuclease-1 (Fen1) was found to improve cell tolerance by counteracting the toxic accumulation of another protein, 53BP1. A renewed spotlight on the underappreciated role of Fen1 promises not only new cancer treatments, but a way to gauge the efficacy of existing treatments.

New research from Memorial Sloan Kettering Cancer Center (MSK) develops a powerful new resource for studying gene regulation across eukaryotes; uncovers how “jumping genes” can drive cancer growth; describes how an unexpected oxygen sensor regulates ferroptosis; establishes a technique to map chromatin architecture in 3D; creates new models for studying schizophrenia-associated defects; and finds transcription factor 19 is critical for the responses of natural killer cells to viral infection.

The growing healthcare burden posed by hepatocellular carcinoma, the most common subtype of liver cancer, has prompted the establishment of a Commission comprising a wide range of medical and public health experts. Now, they present their findings in a recent report, which defines concrete goals for the reduction of hepatocellular carcinoma cases, and presents a set of evidence-based recommendations to help stakeholders work together to achieve these goals.

Professor Xun Lan from the School of Basic Medical Sciences at Tsinghua University and Director Hongxing Liu from Hebei Yanda Lu Daopei Hospital have published a research article entitled “Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML” in Science Bulletin. This study leverages single-cell multi-omics technologies to investigate the regulatory aberrations caused by mutations in the transcription factor WT1 and in cis-regulatory elements that drive acute myeloid leukemia (AML). The research also uncovers tumor clones and relapse-associated markers linked to AML relapse, offering new insights into the mechanisms of disease progression and potential avenues for therapeutic intervention.