Advancing lung cancer treatment: Understanding the differences between LUAD and LUSC
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Jul-2025 00:10 ET (11-Jul-2025 04:10 GMT/UTC)
Lung cancer remains one of the leading causes of cancer-related mortality, with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) representing the most prevalent subtypes of non-small cell lung cancer (NSCLC). Despite their classification under the same umbrella, these two forms of lung cancer exhibit distinct genetic landscapes, therapeutic targets, and treatment responses.
This study explores the potential of oncomicrobial vaccines in mitigating tumor progression by targeting specific cancer-promoting microbes in mice. The researchers developed and tested vaccines against Campylobacter jejuni (C. jejuni) and enterotoxigenic Bacteroides fragilis (ETBF), both of which are associated with colorectal cancer (CRC). The vaccines effectively reduced the colonization of these oncomicrobes, suppressed tumor development, and mitigated inflammation without significantly disrupting the gut microbiota. The findings suggest that oncomicrobial vaccines could be a promising strategy for preventing and treating CRC, particularly in individuals at high risk due to family history or other factors.
Mass General Brigham-led researchers investigated data from over 200,000 individuals who were followed for more than 30 years, and found that higher intake of plant-based oils, especially soybean, canola, and olive oil, was associated with lower total, cancer, and cardiovascular disease mortality, whereas butter intake was associated with increased risk of total and cancer mortality. The researchers also found that less than a tablespoon of butter per day with equivalent calories of plant-based oils could lower cancer deaths and overall mortality by 17%.
Chemotherapy and immunotherapy followed by de-escalated chemoradiation showed increased survival and reduced side effects in aggressive head and neck cancers that are not associated with human papillomavirus (HPV) infection, according to a new study.
More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes often have worse outcomes.
A new study by researchers from Boston University Chobanian & Avedisian School of Medicine helps explain why this happens and suggests a potential way to improve treatment for these patients.