Basic research on Listeria bacteria leads to unique cancer therapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 19:15 ET (22-Jun-2026 23:15 GMT/UTC)
Listeria bacteria generate a unique innate immune response that is being harnessed to boost the immune system in cancer patients. Scientists at UC Berkeley and a spinoff company eliminated the bacteria’s ability to cause disease while retaining its ability to rev up production of gamma delta T cells, which are associated with increased survival in cancer patients. They demonstrated the therapy’s safety in mice and seek approval to test it in pediatric leukemia patients.
This year’s Sjöberg Prize of one million US dollars is awarded to a British cancer researcher who has provided fundamental knowledge about evolution in tumours. Charles Swanton, at the Francis Crick Institute in London, has described how tumours’ mutations arise and develop. His discoveries could help explain why treatments do not always work, as well as leading the way to more accurate diagnostics.