Rational design of multifunctional nanoplatforms capable of combining therapeutic effects with real-time monitoring of drug distribution and tumor status is emerging as a promising approach in cancer nanomedicine. Here, we introduce pyropheophorbide a–bisaminoquinoline conjugate lipid nanoparticles (PPBC LNPs) as a bimodal system for image-guided phototherapy in bladder cancer treatment. PPBC LNPs not only demonstrate both powerful photodynamic and photothermal effects upon light activation, but also exhibit potent autophagy blockage, effectively inducing bladder cancer cell death. Furthermore, PPBC LNPs possess remarkable photoacoustic (PA) and fluorescence (FL) imaging capabilities, enabling imaging with high-resolution, deep tissue penetration and high sensitivity for tracking drug biodistribution and phototherapy efficacy. Specifically, PA imaging confirms the efficient accumulation of PPBC LNPs within tumor and predicts therapeutic outcomes of photodynamic therapy, while FL imaging confirms their prolonged retention at the tumor site for up to 6 days. PPBC LNPs significantly suppress bladder tumor growth, with several tumors completely ablated following just two doses of the nanoparticles and laser treatment. Additionally, PPBC LNPs were formulated with lipid-based excipients and assembled using microfluidic technology to enhance biocompatibility, stability, and scalability, showing potential for clinical translation. This versatile nanoparticle represents a promising candidate for further development in bladder cancer therapy.

Abstract

Purpose – This article aims to examine whether corporate green investment intentions were inhibited by the online concerns of retail investors, a group accounting for more than 90% of the total stock investors in China.

Design/methodology/approach – A panel regression model is used to examine whether retail investor concerns inhibit corporate green investment intentions based on data from Chinese listed companies and data extracted from online social platforms where retail investors exchange information from 2010 to 2022. Machine learning methods are used to construct text word frequency indicators representing corporate green investment intentions. A series of endogeneity and robustness tests and a heterogeneity analysis are used to examine the regression results.

Findings – This article finds that retail investor concerns shown on online social platforms significantly inhibit corporate green investment intentions. The inhibition effect comes from the investment stages of source prevention and process control, while a promotion effect is identified at the stage of end-pipe treatment. Furthermore, the inhibition effect is smaller for companies with improved credibility of information disclosure.

Originality/value – This article innovatively uses the word frequency construction method based on text data to measure green investment intentions after clarifying the concept of green investment, which differs from green transformation, social responsibility, green finance and other popular terms. This article focuses on the emerging online social platform instead of discussing the function and mechanism of traditional information intermediaries. By verifying the market pressure caused by retail investor concerns about corporate green investment, this article expands the coverage of the market pressure hypothesis from traditional media to online social platforms and provides an empirical basis for implementing the national policy of de-retailer. This article’s validation of endogeneity is comprehensive compared to the literature on the selection of instrumental variables based on regional or sectoral averages.

The most comprehensive analysis of rheumatoid arthritis data to date reveals that demographic changes and uneven health infrastructure have exacerbated the rheumatoid arthritis burden since 1980 and shows global disparities on a granular level. The AI-powered study in the Annals of the Rheumatic Diseases, published by Elsevier, utilized deep learning techniques and policy simulations to uncover actionable insights for localized interventions that national-level studies have previously missed. Its design yielded highly precise, dynamic projections of further disease burden to 2040.

A sweeping new review reveals how satellites are helping scientists track a quiet but widespread shift in global agriculture: the abandonment of cropland.