29-Oct-2025
Proteins critical to cell electrical signaling built from scratch
University of Washington School of Medicine/UW MedicinePeer-Reviewed Publication
Protein designers have now created new calcium channels, built bottom-up from scratch. Naturally occurring ion channels, present in the membrane of excitable cells, generate electrical impulses. These electrophysiological signals help direct muscle contraction, the heartbeat and the release of neurotransmitters. Synthetic ion channels could serve as tools for biomedical research, from neuroscience experiments to heart biology models and synthetic cell signaling circuits.
- Journal
- Nature
- Funder
- Audacious Project, Howard Hughes Medical Institute, Bill and Melinda Gates Foundation, Wu Tsai Protein Innovation Fund, Open Philanthropy Project, Alexandria Venture Investments Translational Investigator Fund, Nan Fung Life Sciences Translational Investigator Fund, BASF Corporation, United States Air Force Office of Scientific Research, DOE/US Department of Energy, NIH/National Institutes of Health